{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:42:01Z","timestamp":1781664121802,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The goal of this study was to determine the prevalence and incidence of neuromyelitis optica spectrum disorder (<jats:styled-content style=\"fixed-case\">NMOSD<\/jats:styled-content>) in Hungary based on the 2015 International Panel of <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> Diagnosis (IPND) criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective population\u2010based cohort study was conducted of 6.4 million Hungarians (age\u00a0\u2265\u00a016 years) between 1 January 2006 and 31 December 2016. Possible <jats:styled-content style=\"fixed-case\">NMOSD<\/jats:styled-content> patients were selected via multistage re\u2010evaluation from multiple sources. Crude and sex\u2010 and serostatus\u2010specific prevalence (per 100\u00a0000 persons) and incidence rates (per 1\u00a0000\u00a0000 person\u2010years) from 2006 to 2015 were estimated and age\u2010adjusted rates were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2262 study candidates, 154 <jats:styled-content style=\"fixed-case\">NMOSD<\/jats:styled-content> patients (age\u00a0\u2265\u00a016 years) with onset until 31 December 2016 were identified based on 2015 <jats:styled-content style=\"fixed-case\">IPND<\/jats:styled-content> criteria. The prevalence analysis on 1 January 2016 included 123 <jats:styled-content style=\"fixed-case\">NMOSD<\/jats:styled-content> living cases, resulting in a prevalence of 1.91 [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.52\u20132.28] per 100\u00a0000 persons. The 101 incident cases emerging from the observed 76\u00a0394\u00a0288 person\u2010years provided an incidence rate of 1.32 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.08\u20131.61) per 1\u00a0000\u00a0000 person\u2010years. Age\u2010adjusted prevalence was 1.87 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.56\u20132.23) per 100\u00a0000 persons and incidence was 1.20 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.98\u20131.46) per 1\u00a0000\u00a0000 person\u2010years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this first report of a large population\u2010based epidemiological study from an Eastern European Caucasian population using robust case validation, a greater prevalence and incidence of <jats:styled-content style=\"fixed-case\">NMOSD<\/jats:styled-content> was found compared to previous large studies in Caucasian populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14079","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T17:58:05Z","timestamp":1567101485000},"page":"308-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["A population\u2010based epidemiological study of neuromyelitis optica spectrum disorder in Hungary"],"prefix":"10.1111","volume":"27","author":[{"given":"V.","family":"Papp","sequence":"first","affiliation":[{"name":"Department of Neurology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Iljicsov","sequence":"additional","affiliation":[{"name":"Department of Neurology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rajda","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Szeged Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Magyari","sequence":"additional","affiliation":[{"name":"Danish Multiple Sclerosis Center Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Koch\u2010Henriksen","sequence":"additional","affiliation":[{"name":"Danish Multiple Sclerosis Center Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Jakab","sequence":"additional","affiliation":[{"name":"Department of Neurology Uzsoki Teaching Hospital Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Deme","sequence":"additional","affiliation":[{"name":"Department of Neurology Somogy County Kaposi M\u00f3r University Teaching Hospital Kaposv\u00e1r Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Neurology Somogy County Kaposi M\u00f3r University Teaching Hospital Kaposv\u00e1r Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Imre","sequence":"additional","affiliation":[{"name":"Department of Neurology Csolnoky Ferenc County University Teaching Hospital Veszpr\u00e9m Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Lohner","sequence":"additional","affiliation":[{"name":"Department of Neurology National Healthcare Services Center Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Neurology P\u00e9terfy Hospital Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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