{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:52:25Z","timestamp":1787727145297,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS09296"],"award-info":[{"award-number":["R21NS09296"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS104398"],"award-info":[{"award-number":["R21NS104398"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Observational studies have implicated migraine as a risk factor for coronary artery disease (CAD) and atrial fibrillation (AF); however, it is unclear whether migraine is causal in this relationship. Potential causality between genetically instrumented liability to migraine and cardiovascular disease outcomes was investigated using two\u2010sample Mendelian randomization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The exposure comprised 35 independent, genome\u2010wide significant genetic variants identified in the largest published genome\u2010wide association study\u00a0of migraine (<jats:italic>N<\/jats:italic><jats:sub>cases<\/jats:sub>\u00a0=\u00a059\u00a0674\/<jats:italic>N<\/jats:italic><jats:sub>controls<\/jats:sub> = 316\u00a0078). The outcome datasets included genome\u2010wide association studies of CAD (76\u00a0014\/264\u00a0785), myocardial infarction (43\u00a0676\/128\u00a0199), angina (10\u00a0618\/326\u00a0065) and AF (60\u00a0620\/970\u00a0216). Mendelian randomization estimates were calculated using inverse\u2010variance weighted regression, and were further assessed with conventional Mendelian randomization sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Evidence was found for a protective effect of migraine liability on CAD (odds ratio 0.86, 95% confidence interval 0.76\u20130.96, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), myocardial infarction (0.86, 0.74\u20130.96, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and angina (0.86, 0.75\u20130.99, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), but not on AF (1.00, 0.95\u20131.05, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.88). Analyses by migraine subtype showed an effect of liability to\u00a0migraine without aura on CAD risk (0.91, 0.84\u20130.99, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.014), but not of migraine with aura (1.00, 0.97\u20131.03, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.89). Sensitivity analyses indicated minimal bias by horizontal pleiotropy, outliers, reverse causality or sample overlap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A potentially protective effect of genetically instrumented liability to migraine on CAD risk was identified. Mechanistic research investigating this link is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14111","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T13:04:56Z","timestamp":1572354296000},"page":"550-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Effect of genetic liability to migraine on coronary artery disease and atrial fibrillation: a Mendelian randomization study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8735-284X","authenticated-orcid":false,"given":"I.","family":"Daghlas","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Preventive Medicine Harvard Medical School Brigham and Women\u2019s Hospital Boston MA USA"},{"name":"Center for Genomic Medicine Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Preventive Medicine Harvard Medical School Brigham and Women\u2019s Hospital Boston MA USA"},{"name":"Program in Genetic Epidemiology and Statistical Genetics Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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