{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:07:49Z","timestamp":1774940869426,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673247"],"award-info":[{"award-number":["81673247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703317"],"award-info":[{"award-number":["81703317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Elevated C\u2010reactive protein (CRP) is associated with an increased risk of ischaemic stroke (IS). However, the causality of this association is uncertain. The aim is to investigate whether genetically raised plasma CRP concentration levels are associated with IS on the basis of the Mendelian randomization method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on the National Center for Biotechnology Information single nucleotide polymorphism (SNP) database, the Chinese online genetic database as well as previously published studies, four CRP\u2010associated SNP alleles (rs1130864, rs1205, rs876537 and rs3093059) with minor allele frequency \u22650.15 were selected and the concentration levels of CRP were measured in 378 first\u2010ever IS patients and 613 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three SNPs were chosen and used as instrumental variables. The adjusted odds ratios (ORs) [95% confidence interval (95% CI)] of IS per addition of the modelled allele were 1.07 (0.79\u20131.45) for rs876537, 0.99 (0.73\u20131.35) for rs1205 and 1.08 (0.71\u20131.65) for rs3093059. The OR (95% CI) of IS for plasma CRP\u00a0\u22652.0\u00a0mg\/l was 2.19 (1.06\u20134.53) compared with &lt;2.0\u00a0mg\/l. The adjusted OR (95% CI) of IS per genetically predicted 10% higher CRP concentration, based on the three SNPs as the instruments, was 1.02 (0.94\u20131.11). Furthermore, similar results were obtained with adjusted ORs (95% CI) of 1.00 (0.88\u20131.13) and 1.04 (0.93\u20131.16), respectively, for large\u2010artery atherosclerosis and small\u2010artery occlusion per genetically predicted 10% higher CRP concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This Mendelian randomization study provides no clear support that elevated CRP concentration is causally associated with the risk of IS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14113","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T13:03:50Z","timestamp":1573045430000},"page":"565-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of plasma C\u2010reactive protein with ischaemic stroke: a Mendelian randomization study"],"prefix":"10.1111","volume":"27","author":[{"given":"X.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Beijing Municipal Key Laboratory of Clinical Epidemiology Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-2877","authenticated-orcid":false,"given":"A.","family":"Wang","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Beijing Municipal Key Laboratory of Clinical Epidemiology Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences Edith Cowan University Joondalup WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Beijing Municipal Key Laboratory of Clinical Epidemiology Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zuo","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Beijing Municipal Key Laboratory of Clinical Epidemiology Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Beijing Municipal Key Laboratory of Clinical Epidemiology Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences Edith Cowan University Joondalup WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Feigin","sequence":"additional","affiliation":[{"name":"National Institute for Stroke and Applied Neurosciences Auckland University of Technology Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Beijing Municipal Key Laboratory of Clinical Epidemiology Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5659-5045","authenticated-orcid":false,"given":"D.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Beijing Municipal Key Laboratory of Clinical Epidemiology Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192666"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000165929.78756.ed"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.525105"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000130422.89335.81"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.513259"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70099-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2004.031880"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3034"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707402"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001976"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.10.1407"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"e001119","DOI":"10.1161\/JAHA.114.001119","article-title":"Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification and vascular territory of ischemic stroke lesions diagnosed by diffusion\u2010weighted imaging","volume":"3","author":"Jong\u2010Won C","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2017.1297905"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8817.2005.00210.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.482661"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064395"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70152-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyl041"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000559"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0276-5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/hs1101.098151"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61717-7"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.11.027"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1289-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.476135"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000231872.86071.68"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706027104"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.872796"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d548"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.131193"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67786-0"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.14113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14113","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T06:03:07Z","timestamp":1694152987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,26]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/ene.14113"],"URL":"https:\/\/doi.org\/10.1111\/ene.14113","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,26]]},"assertion":[{"value":"2019-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}