{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:03:36Z","timestamp":1790899416363,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T00:00:00Z","timestamp":1576972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Cholinergic dysfunction appears to play a role in the cognitive impairment observed in Parkinson\u2019s disease and dementia with Lewy bodies. The occurrence of cholinergic dysfunction in the early stages of these conditions, however, has not been investigated. The objective of this study was to investigate cholinergic function in patients with idiopathic rapid eye movement sleep behaviour disorder (iRBD), a disorder recognized to be an early stage of both Parkinson\u2019s disease and dementia with Lewy bodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 21 patients with polysomnography\u2010confirmed iRBD with no evidence of parkinsonism and cognitive impairment and 10 controls underwent positron emission tomography (PET) to assess brain acetylcholinesterase levels (<jats:sup>11<\/jats:sup>C\u2010donepezil PET) and nigrostriatal dopaminergic function (<jats:sup>18<\/jats:sup>F\u2010DOPA PET). Clinical examination included the Movement Disorder Society\u2013Unified Parkinson\u2019s Disease Rating Scale part III, Mini Mental State Examination and Montreal Cognitive Assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:sup>11<\/jats:sup>C\u2010donepezil PET was successfully performed in 17 patients with iRBD and nine controls. Compared with controls, patients with iRBD showed a mean 7.65% reduction in neocortical <jats:sup>11<\/jats:sup>C\u2010donepezil levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). Bilateral superior temporal cortex, occipital cortex, cingulate cortex and dorsolateral prefrontal cortex showed the most significant reductions at voxel level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced neocortical <jats:sup>11<\/jats:sup>C\u2010donepezil binding in our patients indicates cholinergic denervation and suggests that the projections from the nucleus basalis of Meynert, which supplies cholinergic innervation to the neocortex, are dysfunctional in iRBD. Longitudinal studies will clarify if these changes are predictive of future cognitive impairment in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14127","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T17:02:53Z","timestamp":1573750973000},"page":"644-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Cholinergic denervation in patients with idiopathic rapid eye movement sleep behaviour disorder"],"prefix":"10.1111","volume":"27","author":[{"given":"M.","family":"Gersel Stokholm","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Centre Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Iranzo","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Cl\u00ednic de Barcelona Barcelona"},{"name":"Centro de Investigaci\u00f3n 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