{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:05:01Z","timestamp":1747184701695,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671182"],"award-info":[{"award-number":["81671182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313228"],"award-info":[{"award-number":["2016A030313228"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Increasing evidence has demonstrated that aquaporin\u20104 (AQP4) immunoglobulin G causes damage to the kidney in neuromyelitis optica spectrum disorder (NMOSD). However, changes in urinalysis in NMOSD have not been investigated thus far. Our objective was to evaluate the changes in urinalysis in NMOSD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case data were collected from 44 patients with AQP4 antibody\u2010positive NMOSD, 53 patients with multiple sclerosis (MS) and 79 age\u2010 and sex\u2010matched healthy controls. Analyses of early morning urine and 24\u2010h urine samples comparing NMOSD with MS patients were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the acute phase, urine pH levels (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and urine specific gravity levels (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) from NMOSD patients were significantly higher and lower, respectively, than for MS patients. 24\u2010h urine sodium and 24\u2010h urine volume from NMOSD patients were significantly higher than for MS patients (both <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). A 24\u2010h urine volume higher than 2500\u00a0ml (odds ratio 11.7, 95% confidence interval 1.863\u201373.066) and a 24\u2010h urine sodium higher than 200\u00a0mmol (odds ratio 16.0, 95% confidence interval 2.122\u2013120.648) are more likely to occur in NMOSD patients in the acute phase than in MS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The urinalysis results were significantly different between NMOSD patients and MS patients. The pathophysiological changes in AQP4 antibody\u2010positive NMOSD patients were not limited to the central nervous system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14128","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T12:10:00Z","timestamp":1573819800000},"page":"619-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Urinalysis in patients with neuromyelitis optica spectrum disorder"],"prefix":"10.1111","volume":"27","author":[{"given":"Z. G.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology and Multiple Sclerosis Research Center Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Department of Neurology Fifth Affiliated Hospital Sun Yat\u2010sen University Zhuhai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology and Multiple Sclerosis Research Center Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. H.","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Neurology and Multiple Sclerosis Research Center Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Department of Neurology Second People's Hospital of Foshan Foshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. T.","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Landis","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0040-4211","authenticated-orcid":false,"given":"Y.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Multiple Sclerosis Research Center Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/361549a0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI231"},{"key":"e_1_2_9_5_1","first-page":"1153","article-title":"Urinalysis: a comprehensive review","volume":"71","author":"Simerville JA","year":"2005","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7748\/ns.19.35.51.s53"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-711-2_1"},{"key":"e_1_2_9_8_1","unstructured":"World Health Organization.Salt Reduction: Fact Sheet. 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Available from:http:\/\/www.who.int\/mediacentre\/factsheets\/fs393\/en\/(accessed 11\/07\/2018)."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.50.168"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2017.05.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2666-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1020-49892012001000010"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13353"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012088488-9.50035-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2003.11.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1681\/ASN.V105913","article-title":"Na\/K\u2010ATPase in intercalated cells along the rat nephron revealed by antigen retrieval","volume":"10","author":"Saboli\u0107 I","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24965"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307928"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200100315"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12714"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(76)90018-4"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14128","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14128","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T20:35:08Z","timestamp":1693859708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,2]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/ene.14128"],"URL":"https:\/\/doi.org\/10.1111\/ene.14128","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"type":"print","value":"1351-5101"},{"type":"electronic","value":"1468-1331"}],"subject":[],"published":{"date-parts":[[2019,12,2]]},"assertion":[{"value":"2019-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}