{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:50:35Z","timestamp":1777359035622,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Little is known about the long\u2010term association between transient ischaemic attack (TIA) and stroke. Therefore, the goal of this study was to analyze the long\u2010term risk of stroke and associated predictors in a large cohort of TIA patients followed in general practices in Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included patients with an initial TIA diagnosis and subsequently followed up in one of 1262 general practices in Germany between January 2007 and December 2016 (<jats:italic>N<\/jats:italic>\u00a0=\u00a019\u00a0824 patients). The primary outcome of the study was the risk of ischaemic stroke within 10\u00a0years of the initial diagnosis of TIA. The secondary outcome was the identification of demographic, clinical and pharmaceutical variables significantly associated with stroke in TIA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within 10\u00a0years of the initial TIA diagnosis, 18.3% of individuals were diagnosed with stroke. Age was positively associated with stroke, with hazard ratios ranging from 1.88 in patients aged 51\u201360\u00a0years to 4.00 in those aged &gt;80\u00a0years (reference group: patients aged \u226450\u00a0years). Furthermore, male sex, hypertension, diabetes mellitus, atrial fibrillation and ischaemic heart diseases had an additional impact on the risk of stroke. Finally, new oral anticoagulants, heparins, diuretics, angiotensin II receptor blockers and platelet aggregation inhibitors were identified as protective factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a cohort of almost 20\u00a0000 TIA patients, 18.3% were diagnosed with stroke within 10\u00a0years after the TIA index event. Several demographic, clinical and pharmaceutical variables significantly predicted the long\u2010term risk of stroke in TIA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14136","type":"journal-article","created":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T14:39:16Z","timestamp":1575729556000},"page":"723-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Long\u2010term risk of stroke and its predictors in transient ischaemic attack patients in Germany"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1071-1239","authenticated-orcid":false,"given":"L.","family":"Jacob","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Versailles Saint\u2010Quentin\u2010en\u2010Yvelines Montigny\u2010le\u2010Bretonneux France"},{"name":"Research and Development Unit Parc Sanitari Sant Joan de D\u00e9u CIBERSAM Barcelona 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