{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:15:49Z","timestamp":1790666149207,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Drug\u2010resistant idiopathic generalized epilepsy (IGE) remains challenging despite a favourable overall prognosis of IGE, and little is known about basic epidemiology and long\u2010term outcome of drug\u2010resistant IGE. The aim of the study was to describe the incidence, prevalence and outcome of IGE in an unbiased, population\u2010based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 2014\u20132018, all patients (\u226517\u00a0years) with IGE inhabiting the island of Funen (496\u00a0000 inhabitants) were recruited. The socioeconomic and clinical information available for 406 individuals was assessed. Median follow\u2010up was 15\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The average IGE incidence (2008\u20132017) was 2.9\/100\u00a0000 inhabitants\/year. The point prevalence of identifiable IGE patients was 1.0\/1000 adults (juvenile myoclonic epilepsy 0.4\/1000; absence epilepsy 0.3\/1000, epilepsy with generalized tonic\u2013clonic seizures alone 0.3\/1000); 92.1% of the patients were diagnosed before 25\u00a0years of age. When correcting for unequal age distribution in the cohort, 1102 people on the island of Funen fulfilled the diagnostic criteria for IGE at the age of 25 (estimated prevalence 2.7\/1000 adults). In the year before data closure, 121 patients reported seizures. Fifty patients met the definition of drug\u2010resistant IGE (12.1% of the cohort, 4.5% of the estimated 1102 IGE patients). The average seizure burden of all patients with drug\u2010resistant IGE was 2.2 generalized tonic\u2013clonic seizures per year; only 14 patients suffered more than two generalized tonic\u2013clonic seizures per year. Drug\u2010resistant IGE was associated with an increased risk of requiring treatment for affective disorders and a reduced probability of working full time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Idiopathic generalized epilepsy was associated with a low risk of persistent drug\u2010resistant seizures requiring specialist medical attention. Drug resistance was associated with a negative socioeconomic outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.14142","type":"journal-article","created":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T05:05:02Z","timestamp":1576386302000},"page":"676-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Epidemiology and outcome of idiopathic generalized epilepsy in adults"],"prefix":"10.1111","volume":"27","author":[{"given":"J.","family":"Gesche","sequence":"first","affiliation":[{"name":"Department of Neurology Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Danish Epilepsy Center Dianalund Denmark"},{"name":"Amplexa Genetics A\/S Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rubboli","sequence":"additional","affiliation":[{"name":"Danish Epilepsy Center Dianalund Denmark"},{"name":"University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8268-1492","authenticated-orcid":false,"given":"C. 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