{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:51:29Z","timestamp":1790419889010,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Anaemia is associated with poor clinical outcome after ischaemic and haemorrhagic stroke. The association between anaemia and outcome in patients with cerebral venous thrombosis (CVT) was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive adult patients with CVT were included from seven centres. Anaemia at admission was scored according to World Health Organization definitions. Poor clinical outcome was defined as a modified Rankin Scale score 3\u20136 at last follow\u2010up. A multiple imputation procedure was applied for handling missing data in the multivariable analysis. Using binary logistic regression analysis, adjustments were made for age, sex, cancer and centre of recruitment (model 1). In a secondary analysis, adjustments were additionally made for coma, intracerebral haemorrhage, non\u2010haemorrhagic lesion and deep venous system thrombosis (model 2). In a sensitivity analysis, patients with cancer were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data for 952 patients with CVT were included, 22% of whom had anaemia at admission. Patients with anaemia more often had a history of cancer (17% vs. 7%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) than patients without anaemia. Poor clinical outcome (21% vs. 11%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and mortality (11% vs. 6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.07) were more common amongst patients with anaemia. After adjustment, anaemia at admission increased the risk of poor outcome [adjusted odds ratio (aOR) 2.4, 95% confidence interval (CI) 1.5\u20133.7, model 1]. Model 2 revealed comparable results (aOR 1.9, 95% CI 1.2\u20133.2), as did the sensitivity analysis excluding patients with cancer (aOR 2.3, 95% CI 1.3\u20133.8, model 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The risk of poor clinical outcome is doubled in CVT patients presenting with anaemia at admission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14148","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T06:56:17Z","timestamp":1577516177000},"page":"716-722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Anaemia at admission is associated with poor clinical outcome in cerebral venous thrombosis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7633-2675","authenticated-orcid":false,"given":"S. M.","family":"Silvis","sequence":"first","affiliation":[{"name":"Department of Neurology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Reinstra","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hiltunen","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lindgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"},{"name":"Department of Neurology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-2159","authenticated-orcid":false,"given":"M. R.","family":"Heldner","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Sina Hospital Hamadan University of Medical Science Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ghiasian","sequence":"additional","affiliation":[{"name":"Sina Hospital Hamadan University of Medical Science Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Jood","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"},{"name":"Department of Neurology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Zuurbier","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"Groot","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Barboza","sequence":"additional","affiliation":[{"name":"Neurosciences Department Hospital Dr R.A. Calder\u00f3n Guardia CCSS San Jos\u00e9 Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Arauz","sequence":"additional","affiliation":[{"name":"National Institute of Neurology and Neurosurgery Manuel Velasco Suarez Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Putaala","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tatlisumak","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Hospital and University of Helsinki Helsinki Finland"},{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"},{"name":"Department of Neurology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the International CVT Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.104"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009843"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000117571.76197.26"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04846.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-201076"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003019"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.09.008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12657"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-018-0544-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e31820a8364"},{"key":"e_1_2_7_12_1","unstructured":"World Health Organization.Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity.2011[Available from:http:\/\/www.who.int\/vmnis\/indicators\/haemoglobin.pdf]"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004666"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000155744.90689.78"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203535"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00403.2006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2004.02.011"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31820cccb2"},{"key":"e_1_2_7_19_1","first-page":"CD002042","article-title":"Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion","volume":"10","author":"Carson JL","year":"2016","journal-title":"Cochrane Database Syst Rev"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.14148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14148","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T20:34:56Z","timestamp":1693859696000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,24]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/ene.14148"],"URL":"https:\/\/doi.org\/10.1111\/ene.14148","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,24]]},"assertion":[{"value":"2019-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}