{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:35:56Z","timestamp":1791974156464,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A2C1004796"],"award-info":[{"award-number":["2019R1A2C1004796"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The patterns of head\u2010shaking nystagmus (HSN) aid in differentiation between central and peripheral vestibular disorders, and perverted HSN (pHSN) has been considered a central sign. The aim was to determine the characteristics of HSN in a large number of patients with either peripheral or central vestibular disorders in a dizziness clinic of a university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 7544 dizzy patients were reviewed during a year and 822 patients with a clinical diagnosis of vestibular disorders were recruited. The findings of spontaneous nystagmus (SN) and HSN in these patients were compared with those of healthy controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 217 of the 822 patients (26.4%) were classified as having a central vestibular disorder, whilst 397 (48.3%) had a peripheral vestibular disorder. In the peripheral vestibular disorder group, SN was observed in 14.1% and HSN in 40.8%, amongst whom 24.1% were the pHSN form. In the central group, SN was observed in 17.5% and HSN in 24.0% of whom 57.7% was pHSN. HSN was more frequently observed in the peripheral vestibular disorder group than in the central group (40.8% vs. 24.0%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). However, the proportion of pHSN was significantly increased in the central group compared to the peripheral vestibular patient group (57.7% vs. 24.1%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Since pHSN is not specific for central vestibular disorders, other clinical features should be considered in pursuing a central lesion in patients with pHSN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14161","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T17:12:05Z","timestamp":1580404325000},"page":"1296-1303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Clinical implications of head\u2010shaking nystagmus in central and peripheral vestibular disorders: is perverted head\u2010shaking nystagmus specific for central vestibular pathology?"],"prefix":"10.1111","volume":"27","author":[{"given":"T.\u2010H.","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology Chonbuk National University Hospital and School of Medicine Jeonju Korea"},{"name":"Research Institute of Clinical Medicine of Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical Medicine of Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital Jeonju Korea"},{"name":"Preventive Medicine Chonbuk National University Hospital and School of Medicine Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3174-1680","authenticated-orcid":false,"given":"S.\u2010Y.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology Chonbuk National University Hospital and School of Medicine Jeonju Korea"},{"name":"Research Institute of Clinical Medicine of Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010J.","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology Chonbuk National University Hospital and School of Medicine Jeonju Korea"},{"name":"Research Institute of Clinical Medicine of Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University College of Medicine Seoul Korea"},{"name":"Dizziness Center Clinical Neuroscience Center Seoul National University Bundang Hospital Seongnam Korea"},{"name":"Department of Neurology Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dieterich","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians\u2010University Munich Germany"},{"name":"German Center for Vertigo and Balance Disorders (IFB<sup>LMU<\/sup>) Ludwig\u2010Maximilians University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","first-page":"S6","article-title":"Physical 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