{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:38:24Z","timestamp":1782412704726,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Tirofiban administration during mechanical thrombectomy (MT) remains controversial. The aim was to evaluate the safety and efficacy of a low\u2010dose rescue tirofiban regimen during MT for Chinese acute ischaemic stroke (AIS) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients from the ANGEL study, a multicentric, prospective registry study that included AIS patients who underwent MT owing to proximal large\u2010artery occlusion from June 2015 to December 2017, were collected. The patients were dichotomized into tirofiban and non\u2010tirofiban groups according to whether rescue tirofiban was performed during MT. Safety outcomes [symptomatic intracerebral haemorrhage (sICH), total intracerebral haemorrhage (ICH) and distal embolization] and efficacy outcomes (artery recanalization and functional outcomes at 3\u2010month follow\u2010up) were compared between groups using logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 662 patients were included in this study, and 230 (34.7%) were in the tirofiban group. No significant differences in safety outcomes on sICH, total ICH and distal embolization and efficacy outcomes on artery recanalization and 3\u2010month functional independence were observed between the tirofiban and non\u2010tirofiban group in the entire cohort or the anterior circulation stroke or posterior circulation stroke patients (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.05 for all groups). However, low\u2010dose rescue tirofiban was significantly correlated with 3\u2010month mortality reduction for posterior circulation stroke patients [adjusted hazard ratio\u00a00.35 (0.14\u20130.92), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low\u2010dose rescue tirofiban during MT was not associated with increased risk of sICH, ICH and distal embolization for AIS patients, and may be correlated with 3\u2010month mortality reduction for posterior circulation stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14170","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T04:35:30Z","timestamp":1581482130000},"page":"1056-1061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Low\u2010dose rescue tirofiban in mechanical thrombectomy for acute cerebral large\u2010artery occlusion"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7788-3356","authenticated-orcid":false,"given":"M.","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Interventional Neuroradiology Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-2877","authenticated-orcid":false,"given":"A.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology Nanjing No. 1 Hospital Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhangzhou City Hospital Zhangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Jilin University Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012360"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362435"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000232317.84122.0c"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5469\/neuroint.2015.10.1.22"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.019193"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000502"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199856060-00017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01078-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2018-000188"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00299"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-018-0679-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.6.1402"},{"key":"e_1_2_8_15_1","first-page":"2595","article-title":"Intravenous 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