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In all, 423 drug\u2010na\u00efve patients with early\u2010stage PD were included in the cross\u2010sectional analysis, and 320 patients who screened negative for any ICDs or related behaviors at baseline were included in the longitudinal analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the cross\u2010sectional analysis, a significant correlation was found between pRBD and ICDs in drug\u2010na\u00efve patients whilst controlling for potential confounders [odds ratio 2.56, 95% confidence interval (CI)\u00a01.38\u20134.76, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003]. In the longitudinal analysis, baseline pRBD was an independent predictor of ICD development over time [hazard ratio (HR) 1.648, 95% CI 1.054\u20132.576; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.028]. Other significant predictors of ICDs included younger age of onset (HR\u00a0=\u00a00.973, 95% CI\u00a0=\u00a00.950\u20130.997; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.026) and greater State\u2010Trait Anxiety Inventory score (HR\u00a0=\u00a01.040, 95% CI\u00a0=\u00a01.020\u20131.061; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest that identifying baseline pRBD in early\u2010stage PD may help clinicians to choose a better therapeutic strategy so as to prevent or limit neuropsychiatric complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14177","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T12:15:57Z","timestamp":1581941757000},"page":"757-763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cross\u2010sectional and longitudinal associations between probable rapid eye 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