{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:38:18Z","timestamp":1792550298413,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>The aim was to investigate the clinical impact of the duration of artificial ventilation in stroke patients receiving mechanical thrombectomy (MT) under general anaesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All consecutive ischaemic stroke patients who had been treated at our centre with MT for anterior circulation large vessel occlusion under general anaesthesia were identified over an 8\u2010year period. Ventilation time was analysed as a continuous variable and patients were grouped into extubation within 6\u00a0h (\u2018early\u2019), 6\u201324\u00a0h (\u2018delayed\u2019) and &gt;24\u00a0h (\u2018late\u2019). Favourable outcome was defined as modified Rankin Scale scores of 0\u20132 at 3 months post\u2010stroke. Pneumonia rate and reasons for prolonged ventilation were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Amongst 447 MT patients (mean age 69.1\u00a0\u00b1\u00a013.3\u00a0years, 50.1% female), the median ventilation time was 3\u00a0h. 188 (42.6%) patients had a favourable 3\u2010month outcome, which correlated with shorter ventilation time (Spearman\u2019s rho\u00a00.39,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). In patients extubated within 24\u00a0h, early compared to delayed extubation was associated with improved outcome (odds ratio 2.40, 95% confidence interval 1.53\u20133.76,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). This was confirmed in multivariable analysis (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01). A longer ventilation time was associated with a higher rate of pneumonia during neurointensive care unit\/stroke unit stay (early\/delayed\/late extubation: 9.6%\/20.6%\/27.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). Whilst stroke\u2010associated complications represented the most common reasons for late extubation (&gt;24\u00a0h), delayed extubation (6\u201324\u00a0h) was associated with admission outside of core working hours (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prolonged ventilation time after stroke thrombectomy independently predicts unfavourable outcome at 3\u00a0months and is associated with increased pneumonia rates. Therefore, extubation should be performed as early as safely possible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.14178","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T06:22:00Z","timestamp":1581920520000},"page":"849-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Ventilation time and prognosis after stroke thrombectomy: the shorter, the better!"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-0378","authenticated-orcid":false,"given":"S.","family":"Fandler\u2010H\u00f6fler","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Heschl","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kneihsl","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Arg\u00fcelles\u2010Delgado","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Niederkorn","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pichler","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Deutschmann","sequence":"additional","affiliation":[{"name":"Department of Radiology Division of Neuroradiology, Vascular and Interventional Radiology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fazekas","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Berghold","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics and Documentation Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Enzinger","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz Graz Austria"},{"name":"Department of Radiology Division of Neuroradiology, Vascular and 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