{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:12:44Z","timestamp":1787919164956,"version":"build-2784847793"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The role of intracranial steno\u2010occlusive disease in cognitive impairment and dementia is unclear and has not been well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 32 consecutive patients (13 males, aged 54\u00a0\u00b1\u00a012\u00a0years) with asymptomatic steno\u2010occlusive middle cerebral artery (MCA) disease, defined as &gt;70% stenosis on maximum intensity projection images or a complete signal loss of MCA trunk on magnetic resonance angiography, and 20 age\u2010 and education\u2010matched normal controls (12 males, 60\u00a0\u00b1\u00a08\u00a0years old) were compared for neuropsychological performance, gray matter volume and neural network analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient group did not show a significant decrease in gray matter volume or cognitive tests except for their performance on the grooved pegboard test. However, graph analysis of resting\u2010state functional magnetic resonance imaging showed significant decreases in network strength, global efficiency and the clustering coefficient, as well as a longer characteristic path length (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The diffusive decrease pattern was particularly located in interhemispheric connectivity and there was no compensatory hyperconnectivity in any brain regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In asymptomatic steno\u2010occlusive MCA disease, cognition and neural network changes are mismatched and have underlying pathophysiological mechanisms that are different from those of neurodegenerative disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14210","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T08:54:17Z","timestamp":1583916857000},"page":"1062-1065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mismatch of cognition and neural networks in asymptomatic middle cerebral artery steno\u2010occlusive disease"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-7456","authenticated-orcid":false,"given":"C.\u2010Y.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010L.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical 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