{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T14:59:18Z","timestamp":1775833158333,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012456","name":"Toronto General and Western Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Background\/Objective<\/jats:title><jats:p>This study aimed to evaluate serum neurofilament light chain (NF\u2010L) levels in former professional contact sports athletes with multiple concussions (ExPro) as a potential biomarker of neurodegeneration and predictor of white\u2010matter (WM) abnormality progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Concentrations of NF\u2010L in the serum of fifty\u2010two cognitively normal ExPro and twenty\u2010one healthy controls (HC) with no history of concussions were measured using single molecule array (Simoa) technology. Both groups underwent neuroimaging at the time of serum collection. Eighteen of the participants in the ExPro underwent follow\u2010up imaging after 2\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Levels of serum NF\u2010L were not significantly different between the ExPro and HC. However, in the ExPro group, NF\u2010L levels were positively correlated with the mean diffusivity (MD) of corpus callosum (CC) and fornix, and total ventricular volume. Moreover, NF\u2010L levels in the ExPro group at the first visit were positively correlated with the amount of increase in CC MD at the 2\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NF\u2010L levels reflect neuronal changes in the ExPro group and predict the extent of decrease in white matter integrity over time. Serum NF\u2010L might be a biomarker of neurodegeneration and WM abnormality progression in ExPro.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14251","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T08:55:22Z","timestamp":1586768122000},"page":"1170-1177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Neurofilament\u2010light in former athletes: a potential biomarker of neurodegeneration and progression"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-2804","authenticated-orcid":false,"given":"F.","family":"Taghdiri","sequence":"first","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Ontario Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Multani","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative 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