{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:11:40Z","timestamp":1790413900381,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Specific respiratory tract infections, including COVID\u201019, may cause smell and\/or taste disorders (STDs) with increased frequency. The aim was to determine whether new\u2010onset STDs are more frequent amongst COVID\u201019 patients than influenza patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a case\u2013control study including hospitalized patients of two tertiary care centres. Consecutive patients positive for COVID\u201019 polymerase chain reaction (cases) and patients positive for influenza polymerase chain reaction (historical control sample) were assessed during specific periods, employing a self\u2010reported STD questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010nine cases and 40 controls were included. No significant differences were found in basal features between the two groups. New\u2010onset STDs were significantly more frequent amongst cases (31, 39.2%) than in the control group (5, 12.5 %) [adjusted odds ratio 21.4 (2.77\u2013165.4, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003)]. COVID\u201019 patients with new\u2010onset STDs were significantly younger than COVID\u201019 patients without STDs (52.6\u00a0\u00b1\u00a017.2 vs. 67.4\u00a0\u00b1\u00a015.1, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Amongst COVID\u201019 patients who presented STDs, 22 (70.9%) recalled an acute onset and it was an initial manifestation in 11 (35.5%). Twenty\u2010five (80.6%) presented smell disorders (mostly anosmia, 14, 45.2%) and 28 (90.3%) taste disorders (mostly ageusia, 14, 45.2%). Only four (12.9 %) reported concomitant nasal obstruction. The mean duration of STD was 7.5\u00a0\u00b1\u00a03.2\u00a0days and 12 patients (40%) manifested complete recovery after 7.4\u00a0\u00b1\u00a02.3\u00a0days of onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>New\u2010onset STDs were significantly more frequent amongst COVID\u201019 patients than influenza patients; they usually had an acute onset and were commonly an initial manifestation. The use of STD assessment in anamnesis as a hint for COVID\u201019 and to support individuals\u2019 self\u2010isolation in the current epidemic context is suggested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14273","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T19:48:17Z","timestamp":1587584897000},"page":"1738-1741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":247,"title":["Acute\u2010onset smell and taste disorders in the context of COVID\u201019: a pilot multicentre polymerase chain reaction based case\u2013control study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2743-0978","authenticated-orcid":false,"given":"\u00c1.","family":"Beltr\u00e1n\u2010Corbellini","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Chico\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mart\u00ednez\u2010Poles","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital La Luz Madrid Spain"},{"name":"Neurological Disorders Study Group Institute for Sanitary and Biomedical Research Cl\u00ednico San Carlos (IdISSC) University Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rodr\u00edguez\u2010Jorge","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5771-5005","authenticated-orcid":false,"given":"E.","family":"Natera\u2010Villalba","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"G\u00f3mez\u2010Corral","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"G\u00f3mez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Monreal","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-4653","authenticated-orcid":false,"given":"P.","family":"Parra\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Cort\u00e9s\u2010Cuevas","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Gal\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fragola\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Porta\u2010Etessam","sequence":"additional","affiliation":[{"name":"Neurological Disorders Study Group Institute for Sanitary and Biomedical Research Cl\u00ednico San Carlos (IdISSC) University Hospital Cl\u00ednico San Carlos Madrid Spain"},{"name":"Department of Neurology University Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1329-0943","authenticated-orcid":false,"given":"J.","family":"Masjuan","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alonso\u2010C\u00e1novas","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63855-7.00001-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63855-7.00025-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2004.06.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000249922.37381.1e"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1127"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa330"},{"key":"e_1_2_8_8_1","article-title":"Coincidence of COVID\u201019 epidemic and olfactory dysfunction outbreak","author":"Reza Bagheri SH","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_8_9_1","article-title":"Early spread of SARS\u2010CoV\u20102 in the Icelandic population","author":"Gudbjartsson DF","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_8_10_1","unstructured":"HillN.COVID\u201019 (corona virus) and smell loss \u2013 guidance from fifth sense Medical Director ENT UK and the British Rhinological Society. Fifth sense: smell taste life.https:\/\/www.fifthsense.org.uk\/covid\u201019\u2010corona\u2010virus\u2010and\u2010smell\u2010loss\u2010guidance\u2010from\u2010fifth\u2010sense\u2010medical\u2010director\/(accessed 19\/03\/2020)."},{"key":"e_1_2_8_11_1","unstructured":"Junta Directiva de la Sociedad Espa\u00f1ola de Neurolog\u00eda.Recomendaciones de la Sociedad Espa\u00f1ola de Neurolog\u00eda (SEN) en relaci\u00f3n con la p\u00e9rdida de olfato como posible s\u00edntoma precoz de infecci\u00f3n por CoVID\u201019.Madrid Spain:Board of Directors of the Spanish Society of Neurology. 21 March2020."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21869"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.14273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14273","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T10:31:06Z","timestamp":1693909866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,16]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/ene.14273"],"URL":"https:\/\/doi.org\/10.1111\/ene.14273","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,16]]},"assertion":[{"value":"2020-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}