{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T21:32:47Z","timestamp":1762896767762,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T00:00:00Z","timestamp":1589673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>In this pooled analysis of seven multicentre cohorts potential differences were investigated in the incidence, characteristics and outcomes between intracranial haemorrhages (ICHs) associated with the use of non\u2010vitamin K antagonist oral anticoagulants (NOAC\u2010ICH) or with vitamin K antagonists (VKA\u2010ICH) in ischaemic stroke patients after oral anticoagulant treatment initiation for atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 4912 eligible AF patients who were admitted in a stroke unit with ischaemic stroke or transient ischaemic attack and who were treated with either VKAs or NOACs within 3\u00a0months post\u2010stroke were included. Fatal ICH was defined as death occurring during the first 30 days after ICH onset. A meta\u2010analysis of available observational studies reporting 30\u2010day mortality rates from NOAC\u2010ICH or VKA\u2010ICH onset was additionally performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 5970 patient\u2010years of follow\u2010up 71 participants had an ICH, of whom 20 were NOAC\u2010ICH and 51 VKA\u2010ICH. Patients in the two groups had comparable baseline characteristics, except for the higher prevalence of kidney disease in VKA\u2010ICH patients. There was a non\u2010significant higher number of fatal ICH in patients with VKAs (11 events per 3385 patient\u2010years) than in those with NOACs (three events per 2623 patient\u2010years; hazard ratio 0.32, 95% confidence interval 0.09\u20131.14). Three\u2010month functional outcomes were similar (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.2) in the two groups. The meta\u2010analysis showed a lower 30\u2010day mortality risk for patients with NOAC\u2010ICH compared to VKA\u2010ICH (relative risk 0.70, 95% confidence interval 0.51\u20130.95).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010vitamin K oral anticoagulants for intracranial haemorrhages and VKA\u2010ICH occurring during secondary stroke prevention of AF patients have comparable baseline characteristics and outcomes except for the risk of fatal ICH within 30\u00a0days, which might be greater in VKA\u2010ICH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14280","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T08:33:46Z","timestamp":1587803626000},"page":"1612-1617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Fatal intracranial haemorrhage occurring after oral anticoagulant treatment initiation for secondary stroke prevention in patients with atrial fibrillation"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-3797","authenticated-orcid":false,"given":"G.","family":"Tsivgoulis","sequence":"first","affiliation":[{"name":"Second Department of Neurology National and Kapodistrian University of Athens School of Medicine Attikon\u2019 University Hospital Athens Greece"},{"name":"Department of Neurology University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-0023","authenticated-orcid":false,"given":"A. H.","family":"Katsanos","sequence":"additional","affiliation":[{"name":"Division of Neurology McMaster University\/Population Health Research Institute Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Seiffge","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Center University Hospital and University of Basel Basel Switzerland"},{"name":"Stroke Research Center Department of Brain Repair and Rehabilitation UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery London UK"},{"name":"Department of Neurology Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Paciaroni","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine University of Perugia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Stroke Research Center Department of Brain Repair and Rehabilitation UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Macha","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cappellari","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neuroscience Azienda Ospedaliera Universitaria Integrata Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kallm\u00fcnzer","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Polymeris","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Center University Hospital and University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2020-8891","authenticated-orcid":false,"given":"V.","family":"Caso","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine University of Perugia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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M.","family":"De Marchis","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Center University Hospital and University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"RAF, RAF\u2010DOAC, CROMIS\u20102, SAMURAI, NOACISP, Erlangen, Verona registry collaborators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-7-199910050-00003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62343-0"},{"key":"e_1_2_8_4_1","first-page":"30521","article-title":"Similar outcomes between vitamin K and non\u2010vitamin K antagonist oral anticoagulants associated intracerebral hemorrhage","author":"Chen SJ","year":"2019","journal-title":"J Formos Med Assoc"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006661"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21917"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005207"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.021979"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016681021"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.04.025"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.04.034"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004362"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002310"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25489"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13742"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25342"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30356-9"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.14280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T02:08:31Z","timestamp":1693361311000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,17]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/ene.14280"],"URL":"https:\/\/doi.org\/10.1111\/ene.14280","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"type":"print","value":"1351-5101"},{"type":"electronic","value":"1468-1331"}],"subject":[],"published":{"date-parts":[[2020,5,17]]},"assertion":[{"value":"2020-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}