{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:31:35Z","timestamp":1790397095817,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Covert paroxysmal atrial fibrillation (pAF) is the most frequent cause of cardiac embolism. Our goal was to discover parameters associated with early pAF detection with intensive cardiac monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Crypto\u2010AF was a multicentre prospective study (four Comprehensive Stroke Centres) to detect pAF in non\u2010lacunar cryptogenic stroke continuously monitored within the first 28\u00a0days. Stroke severity, infarct pattern, large vessel occlusion (LVO) at baseline, electrocardiography analysis, supraventricular extrasystolia in the Holter examination, left atrial volume index and brain natriuretic peptide level were assessed. The percentage of pAF detection and pAF episodes lasting more than 5\u00a0h were registered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 296 patients, 264 patients completed the monitoring period with 23.1% (61\/264) of pAF detection. Patients with pAF were older [odds ratio (OR) 1.04, 95% confidence interval (CI) 1.01\u20131.08], they had more haemorrhagic infarction (OR 4.03, 95% CI 1.44\u201311.22), they were more likely to have LVO (OR 4.29, 95% CI 2.31\u20137.97) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), they had a larger left atrial volume index (OR 1.03, 95% CI 1.01\u20131.1) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002) and they had a higher level of brain natriuretic peptide (OR 1.01, 95% CI 1.0\u20131.1). Age and LVO were independently associated with pAF detection (OR 1.06, 95% CI 1.00\u20131.16, and OR 4.58, 95% CI 2.27\u2013 21.38, respectively). Patients with LVO had higher cumulative incidence of pAF (log rank <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and more percentage of pAF\u00a0&gt;\u00a05\u00a0h [29.6% (21\/71) vs. 8.3% (12\/144); OR 4.62, 95% CI 2.11\u201310.08; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001]. In a mean follow\u2010up of 26.82\u00a0months (SD 10.15) the stroke recurrence rate was 4.6% (12\/260).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Large vessel occlusion in cryptogenic stroke emerged as an independent marker of pAF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14281","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T15:32:09Z","timestamp":1588174329000},"page":"1618-1624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Large vessel occlusion is independently associated with atrial fibrillation detection"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-1369","authenticated-orcid":false,"given":"J.","family":"Pagola","sequence":"first","affiliation":[{"name":"Stroke Unit Neurology Department and Medicine Department Vall d'Hebr\u00f3n Hospital and Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Juega","sequence":"additional","affiliation":[{"name":"Stroke Unit Neurology Department and Medicine Department Vall d'Hebr\u00f3n Hospital and Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Francisco\u2010Pascual","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit Cardiology Department Vall d'Hebr\u00f3n Hospital Barcelona Spain"},{"name":"CIBER\u2010CV. Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory Vall d'Hebr\u00f3n Research Institute Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Penalba","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory Vall d'Hebr\u00f3n Research Institute Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pala","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory Vall d'Hebr\u00f3n Research Institute Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Stroke Unit Neurology Department and Medicine Department Vall d'Hebr\u00f3n Hospital and Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"De Lera Alfonso","sequence":"additional","affiliation":[{"name":"Stroke Unit University Hospital of Valladolid Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Arenillas","sequence":"additional","affiliation":[{"name":"Stroke Unit University Hospital of Valladolid Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Cabezas","sequence":"additional","affiliation":[{"name":"Stroke Unit University Hospital Virgen del Rocio Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Moniche","sequence":"additional","affiliation":[{"name":"Stroke Unit University Hospital Virgen del Rocio Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"de Torres","sequence":"additional","affiliation":[{"name":"Stroke Unit University Hospital Virgen Macarena Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Montaner","sequence":"additional","affiliation":[{"name":"Stroke Unit University Hospital Virgen Macarena Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Gonz\u00e1lez\u2010Alujas","sequence":"additional","affiliation":[{"name":"CIBER\u2010CV. Instituto de Salud Carlos III Madrid Spain"},{"name":"Echocardiography Laboratory Cardiology Department Vall d'Hebr\u00f3n Hospital Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Alvarez\u2010Sabin","sequence":"additional","affiliation":[{"name":"Stroke Unit Neurology Department and Medicine Department Vall d'Hebr\u00f3n Hospital and Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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