{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:02:07Z","timestamp":1791889327296,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T00:00:00Z","timestamp":1592006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>The aim was to investigate whether female reproductive factors are associated with dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In all, 4\u00a0696\u00a0633 post\u2010menopausal women without dementia were identified using the Korean National Health Insurance System database. Data on reproductive factors were collected using a self\u2010administered questionnaire. Dementia was determined using dementia diagnosis codes and anti\u2010dementia drug prescription. Cox proportional hazards regression was conducted to assess the hazard ratio (HR) for dementia according to reproductive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a median follow\u2010up of 5.74\u00a0years, there were 212\u00a0227 new cases of all\u2010cause dementia (4.5%), 162\u00a0901 cases of Alzheimer\u2019s disease (3.5%) and 24\u00a0029 cases of vascular dementia (0.5%). The HR of dementia was 1.15 [95% confidence interval (CI) 1.03\u20131.16] for menarcheal age \u226517\u00a0years compared with menarcheal age 13\u201314\u00a0years, 0.79 (0.77\u20130.81) for menopausal age \u226555\u00a0years compared with menopausal age &lt;40\u00a0years, and 0.81 (0.79\u20130.82) for fertility duration \u226540\u00a0years compared with fertility duration &lt;30\u00a0years. Whilst being of parity one (HR 0.89, 95% CI 0.85\u20130.94) and breastfeeding &lt;6\u00a0months (HR 0.92, 95% CI 0.88\u20130.95) was associated with lower risk of dementia, being of parity two or more (HR 1.04, 95% CI 0.99\u20131.05) and breastfeeding \u226512\u00a0months (HR 1.14, 95% CI 1.01\u20131.07) was associated with a higher risk of dementia than women without parity or breastfeeding history. Use of hormone replacement therapy and oral contraceptives independently reduced the dementia risk by 15% and 10%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Female reproductive factors are independent risk factors for dementia incidence, with higher risk associated with shorter lifetime endogenous estrogen exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.14315","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T17:40:30Z","timestamp":1589305230000},"page":"1448-1458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Female reproductive factors and the risk of dementia: a nationwide cohort study"],"prefix":"10.1111","volume":"27","author":[{"given":"J. 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