{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:38:58Z","timestamp":1774438738315,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Systematic research on the effect of Charcot\u2013Marie\u2013Tooth (CMT) disease on the outcome of pregnancy and conversely the effect of pregnancy on neuropathy is still sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A clinical cohort study and cross\u2010sectional study within the German CMT\u2010NET was conducted between 2016 and 2019. Inclusion criteria were a confirmed diagnosis of CMT and at least one completed pregnancy after 1990. All participants agreed to fill in questionnaires and have their medical files reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group comprised 54 women with a total of 98 pregnancies. The mean age at onset of CMT disease was 12.6\u00a0years (range 0\u201337\u00a0years). Fifty (92%) patients had autosomal dominant CMT; two patients each (4%) had X\u2010linked and autosomal recessive CMT. Forty patients (74%) had a <jats:italic>PMP22<\/jats:italic> gene duplication (CMT1A). Obstetric complications did not differ significantly from a German reference population, neither in the whole group nor in the CMT1A group. Overall there was no increased newborn morbidity and mortality. About one\u2010third of patients reported exacerbation of CMT disease in or after pregnancy. No adverse effects of anaesthesia were reported. Most participants stressed a positive attitude and awareness of challenges associated with pregnancy. Important issues were assistance and support in caring for the family.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In line with findings from our previous study undertaken in the 1990s, there were no increased complication rates for pregnancy and delivery. These results are reassuring for the vast majority of CMT patients and are important for family planning and clinical care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14317","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T08:58:50Z","timestamp":1589360330000},"page":"1390-1396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Pregnancy outcome in Charcot\u2013Marie\u2013Tooth disease: results of the CMT\u2010NET cohort study in Germany"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8332-0672","authenticated-orcid":false,"given":"S.","family":"Rudnik\u2010Sch\u00f6neborn","sequence":"first","affiliation":[{"name":"Institute of Human Genetics Medical University Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Neurology Friedrich\u2010Baur\u2010Institute Ludwigs\u2010Maximilian University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Neurology Friedrich\u2010Baur\u2010Institute Ludwigs\u2010Maximilian University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Reinecke","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology University Medical Centre G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sereda","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology University Medical Centre G\u00f6ttingen G\u00f6ttingen Germany"},{"name":"Department of Neurogenetics Max\u2010Planck\u2010Institute of Experimental Medicine G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Sch\u00f6neborn","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Medical University Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Elbracht","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Medical Faculty RWTH Aachen University Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1994.tb04009.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.10.2011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.02.020"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000150933.65709.96"},{"key":"e_1_2_8_6_1","unstructured":"Statistisches Bundesamt: Durchschnittliches Alter der M\u00fctter bei der Geburt ihrer ehelich lebendgeborenen Kinder (Geburtsjahrmethode) Bev\u00f6lkerung und Erwerbst\u00e4tigkeit: Nat\u00fcrliche Bev\u00f6lkerungsbewegung Pressemitteilung Nr. 005\/2012 Pressemitteilung Nr. 294\/2011 Geburten in Deutschland 2012."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.055"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1023283"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2011.05.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12594"},{"key":"e_1_2_8_11_1","unstructured":"Orphanet: Anaesthesia recommendations for patients suffering from Charcot\u2013Marie\u2013Tooth disease.www.orphananestesia.eu(download 08.03.2020)."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1417-1"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.14317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14317","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T02:07:42Z","timestamp":1693361262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/ene.14317"],"URL":"https:\/\/doi.org\/10.1111\/ene.14317","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]},"assertion":[{"value":"2020-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}