{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:23:16Z","timestamp":1791235396192,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01 EO 0901"],"award-info":[{"award-number":["01 EO 0901"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003493","name":"Gemeinn\u00fctzige Hertie-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003493","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Acute vestibular symptoms have a profound impact on patients\u2019 well\u2010being. In this study, health\u2010related quality of life (HRQoL) and functional impairment were investigated prospectively in patients with different peripheral and central vestibular disorders during the acute symptomatic stage to decipher the most relevant underlying factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In all, 175 patients with acute vestibular disorders were categorized as central vestibular (CV,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040), peripheral vestibular (PV,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a068) and episodic vestibular disorders (EV,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a067). All patients completed scores to quantify generic HRQoL (European Quality of Life Score Five Dimensions Five Levels, EQ\u20105D\u20105L) and disease\u2010specific HRQoL (Dizziness Handicap Inventory, DHI). Vestibular\u2010ocular motor signs were assessed by video\u2010oculography, vestibular\u2010spinal control by posturography and verticality perception by measurement of subjective visual vertical.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with PV had a poorer HRQoL compared to patients with CV and EV (EQ\u20105D\u20105L\/DHI: PV, 0.53\u00a0\u00b1\u00a00.31\/56.1\u00a0\u00b1\u00a019.7; CV, 0.66\u00a0\u00b1\u00a00.28\/43.3\u00a0\u00b1\u00a024.0; EV, 0.75\u00a0\u00b1\u00a00.24\/46.7\u00a0\u00b1\u00a021.4). After adjusting for age, gender, cardiovascular risk factors and non\u2010vestibular brainstem\/cerebellar dysfunction patients with PV persisted to have poorer generic and disease\u2010specific HRQoL (EQ\u20105D\u20105L \u22120.17, DHI +11.2) than patients with CV. Horizontal spontaneous nystagmus was a highly relevant factor for subgroup differences in EQ\u20105D\u20105L and DHI, whilst vertical spontaneous nystagmus, subjective visual vertical and sway path were not. EQ\u20105D\u20105L decreased significantly with more intense horizontal subjective visual vertical in CV (rho\u00a0=\u00a0\u22120.57) and PV (rho\u00a0=\u00a0\u22120.5) but not EV (rho\u00a0=\u00a0\u22120.13).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with PV have the highest functional impairment of all patients with acute vestibular disorders. Vestibular\u2010ocular motor disturbance in the yaw plane has more impact than vestibular\u2010spinal or vestibular\u2010perceptive asymmetry in the roll and pitch plane, suggesting that horizontal visual stability is the most critical for HRQoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.14318","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T04:45:43Z","timestamp":1589345143000},"page":"2089-2098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Health\u2010related quality of life and functional impairment in acute vestibular disorders"],"prefix":"10.1111","volume":"27","author":[{"given":"K.","family":"M\u00f6hwald","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital, LMU Munich Munich Germany"},{"name":"German Center for Vertigo and Balance Disorders DSGZ, LMU Munich Munich 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