{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:22:51Z","timestamp":1773163371780,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601010"],"award-info":[{"award-number":["81601010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701039"],"award-info":[{"award-number":["81701039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870843"],"award-info":[{"award-number":["81870843"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The objective of the study was to investigate the relationship between <jats:italic>IL1R2<\/jats:italic> rs34043159 and Alzheimer\u2019s disease (AD) in the Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 500 AD patients and 500 healthy controls were recruited. The SNaPshot technique was used to detect <jats:italic>IL1R2<\/jats:italic> rs34043159.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The dominant and recessive models of <jats:italic>IL1R2<\/jats:italic> rs34043159 were associated with AD with or without adjustment of age, gender and education [dominant model, <jats:italic>P<\/jats:italic> = 0.019, odds ratio (OR) 1.42, 95% confidence interval (CI) 1.06\u20131.89, adjusted; recessive model, <jats:italic>P<\/jats:italic> = 0.011, OR 0.69, 95% CI 0.51\u20130.92, adjusted]. The recessive model of <jats:italic>IL1R2<\/jats:italic> rs34043159 was associated with early\u2010onset AD (EOAD) with or without adjustment of age, gender and education (recessive model, <jats:italic>P<\/jats:italic> = 0.038, OR 0.60, 95% CI 0.37\u20130.97, adjusted). The additive model was associated with late\u2010onset AD (LOAD) (<jats:italic>P<\/jats:italic> = 0.041). The dominant model of <jats:italic>IL1R2<\/jats:italic> rs34043159 was associated with LOAD with or without adjustment of age, gender and education (dominant model, <jats:italic>P<\/jats:italic> = 0.005, OR 1.68, 95% CI 1.17\u20132.44, adjusted).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An association between the dominant and recessive model of <jats:italic>IL1R2<\/jats:italic> rs34043159 and AD was found. The recessive model of <jats:italic>IL1R2<\/jats:italic> rs34043159 was associated with EOAD. The additive and dominant models of <jats:italic>IL1R2<\/jats:italic> rs34043159 were associated with LOAD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14319","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T23:49:59Z","timestamp":1589413799000},"page":"1844-1847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of <i>IL1R2<\/i> rs34043159 with sporadic Alzheimer\u2019s disease in southern Han Chinese"],"prefix":"10.1111","volume":"27","author":[{"given":"K.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology Shanghai East Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shanghai East Hospital Tongji University School of Medicine Shanghai 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