{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:28:15Z","timestamp":1790288895042,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Malignant middle cerebral artery infarction (MMI) is a severe complication of acute ischaemic stroke (AIS). The aim of our study was to assess whether successful reperfusion after endovascular therapy (EVT) in AIS with clinical and imaging predictors of MMI decreased its occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected between January 2014 and July 2018 in a monocentric prospective AIS registry of patients treated with EVT. Patients selected were &lt;65\u00a0years old with severe anterior circulation AIS with a National Institutes of Health Stroke Scale score &gt;15, baseline Diffusion\u2010Weighted Imaging\u2010Alberta Stroke Program Early Computed Tomography Score\u00a0\u2264\u00a06 and baseline diffusion\u2010weighted imaging lesion volume &gt;82\u00a0mL within 6\u00a0h of symptom onset. Successful reperfusion was defined as a Thrombolysis in Cerebral Ischemia score\u00a0\u2265\u00a02b. Occurrence of MMI was the primary endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 66 EVT\u2010treated patients were included in our study. MMI occurred in 27 patients (41%). In unadjusted analysis, successful reperfusion was associated with fewer MMIs (31.8% vs. 65.0%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015) and with more favorable outcome at 3\u00a0months (50% vs. 20%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023). In multivariate analysis, successful reperfusion was associated with an adjusted odds ratio (95% confidence intervals) of 0.35 (0.10\u20131.12) for MMI and 2.77 (0.84\u201310.43) for 3\u2010month favorable outcome occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early successful reperfusion performed in patients with AIS with clinical and imaging predictors of MMI was associated with decreased MMI occurrence. Reperfusion status might be considered in evaluating the need for craniectomy in patients with early predictors of MMI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14330","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T08:43:19Z","timestamp":1589964199000},"page":"1988-1995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Early successful reperfusion after endovascular therapy reduces malignant middle cerebral artery infarction occurrence in young patients with large diffusion\u2010weighted imaging lesions"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-2694","authenticated-orcid":false,"given":"C.","family":"Sabben","sequence":"first","affiliation":[{"name":"Department of Neurology Rothschild Foundation Hospital Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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