{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:17:26Z","timestamp":1785291446434,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The silent progression of patients with multiple sclerosis (MS) has been reported. The aim of this study was to investigate the association between brain atrophy rates and disease\u2010modifying drugs (DMDs) in patients with MS during their relapse\u2010free period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with relapsing\u2010remitting MS were classified into two groups on the basis of clinical records, i.e. a first\u2010generation DMD group treated with interferon\u2010beta\u20101a, interferon\u2010beta\u20101b or glatiramer acetate and a second\u2010generation DMD group treated with dimethyl fumarate, fingolimod or natalizumab. Brain volume was calculated with SPM12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 45 patients with relapsing\u2010remitting MS were enrolled in the first\u2010generation (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) or second\u2010generation (<jats:italic>n<\/jats:italic>\u00a0=\u00a023) DMD group. The annualized relapse rate was lower in the first\u2010generation than in the second\u2010generation DMD group (median 0.26 vs. 0.59; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The annualized atrophy rate of the normalized brain volume was not different between the first\u2010 and second\u2010generation DMD groups after analysis of covariance (median 0.13% vs. 0.59%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.17).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The median annualized atrophy rate of normalized brain volume in the first\u2010generation DMD group was similar to the previously reported annual brain atrophy rate of healthy controls, which may suggest that treatment with a first\u2010generation DMD need not be changed when patients with MS are clinically inactive.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14335","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T19:57:27Z","timestamp":1589918247000},"page":"2056-2061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of brain atrophy in patients with multiple sclerosis treated with first\u2010 versus second\u2010generation disease modifying therapy without clinical relapse"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-6482","authenticated-orcid":false,"given":"H.","family":"Masuda","sequence":"first","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8767-255X","authenticated-orcid":false,"given":"M.","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-1863","authenticated-orcid":false,"given":"A.","family":"Uzawa","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7075-341X","authenticated-orcid":false,"given":"R.","family":"Ohtani","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13929"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25145"},{"key":"e_1_2_6_5_1","volume-title":"Multiple Sclerosis and Related Disorders: Diagnosis, Medical Management, and Rehabilitation","author":"Rae\u2010Grant 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