{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:46:27Z","timestamp":1775713587884,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Little evidence exists to describe the incidence and risk factors for dementia in developing countries. This study aimed to examine the incidence and factors associated with the risk of developing dementia in a Thai general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on 206\u00a0073 men and women aged \u226550\u00a0years participating in the Health Check Ubon Ratchathani Project in 2006 were merged with diagnostic information from the hospital\u2019s electronic medical records in the following 6\u00a0years (2006\u20132012). The incidence of physician\u2010diagnosed dementia over 6\u00a0years was examined. Factors associated with the risk of developing dementia were examined using multivariate Cox proportional hazard regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a total time at risk of 1\u00a0196\u00a0433 person\u2010years, 480 individuals developed dementia; the incidence rate was 0.40 [95% confidence interval (CI) 0.37\u20130.44] per 1000 person\u2010years. Dementia incidence rose exponentially with increasing age to 1.37 (95% CI 1.07\u20131.75) per 1000 person\u2010years in those aged 80\u201384\u00a0years and dropped after the age of 85\u00a0years. Factors independently associated with the risk of developing dementia included increasing age, diabetes and lack of physical exercise. The risk of dementia rose by 7% for every 1\u00a0year of age older [adjusted hazard ratio (aHR) 1.07, 95% CI 1.06\u20131.08]. Diabetes increased the risk of dementia by 51% (aHR 1.51, 95% CI 1.12\u20132.03). Compared to no physical exercise, having 3\u20135\u00a0days\/week and&gt;\u00a05\u00a0days\/week of physical exercise reduced the risk of dementia by 37% and 59% (aHR 0.63, 95% CI 0.50\u20130.79, and 0.41, 95% CI 0.26\u20130.66, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dementia incidence in a Thai population was lower than Western populations and its independent risk factors included increasing age, diabetes and a lack of physical exercise. Adequate physical exercise may counterbalance the ageing process, the main drive of dementia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14354","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T09:59:15Z","timestamp":1590141555000},"page":"1879-1886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dose\u2013response relationship between physical exercise and risk of physician\u2010diagnosed dementia in 206\u00a0073 Thai community\u2010dwelling men and women: HCUR study"],"prefix":"10.1111","volume":"27","author":[{"given":"P.","family":"Boongird","sequence":"first","affiliation":[{"name":"Dementia Association of Thailand  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5202-4149","authenticated-orcid":false,"given":"P.","family":"Chamnan","sequence":"additional","affiliation":[{"name":"Cardiometabolic Research 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