{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:42:12Z","timestamp":1776472932525,"version":"3.51.2"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/01766\u20107"],"award-info":[{"award-number":["2013\/01766\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/26410\u20100"],"award-info":[{"award-number":["2013\/26410\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Neurological manifestations have been identified in the context of autoimmune hepatitis (AIH). Previous case reports highlighted the association between AIH and sensory neuronopathy (SN). Despite that, little is known about the frequency of AIH\u2010related SN and its clinical\/neurophysiological profile. Moreover, it is not clear whether SN is an AIH\u2010specific manifestation or related to chronic liver damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy consecutive AIH patients were enrolled and their characteristics were compared with 52 consecutive patients with chronic active hepatitis B. All subjects underwent clinical and neurophysiological evaluation. Further comparisons were performed between AIH SN and AIH non\u2010SN patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean ages and male:female proportions in the AIH and chronic active hepatitis B groups were 42.2\u00a0\u00b1\u00a016.3\/51.7\u00a0\u00b1\u00a013.6\u00a0years and 14:56\/29:23, respectively. The frequencies of carpal tunnel syndrome, radiculopathy and polyneuropathy were similar between groups. In contrast, SN was identified only in AIH patients (5\/70 vs. 0\/52, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04); the overall prevalence of AIH\u2010related SN was 7% with an average profile of a woman in her 40s with asymmetric onset of sensory deficits that chronically evolved to disabling proprioceptive ataxia associated with marked dysautonomia. Neurological disability and hepatocellular damage did not follow in parallel. Anti\u2010fibroblast growth factor receptor type 3 antibodies were found in 3\/5 (60%) of the patients with AIH\u2010related SN. Clinical or demographic predictors of SN in the context of AIH could not be identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sensory neuronopathy, but not other peripheral nervous system diseases, is a specific AIH neurological manifestation. It is often disabling and, in contrast to hepatocellular injury, does not respond to immunosuppression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14355","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T12:43:39Z","timestamp":1590151419000},"page":"2072-2078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sensory neuronopathy is a specific and disabling neurological manifestation of autoimmune hepatitis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-0853","authenticated-orcid":false,"given":"A. R. M.","family":"Martinez","sequence":"first","affiliation":[{"name":"Department of Neurology \u2013 Neuromuscular Division University of Campinas (UNICAMP) Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. D.","family":"de Lima","sequence":"additional","affiliation":[{"name":"Department of Neurology \u2013 Neuromuscular Division University of Campinas (UNICAMP) Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Neurology \u2013 Neuromuscular Division University of Campinas (UNICAMP) Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. E.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2013 Gastroenterology Division (Gastrocentro) University of Campinas (UNICAMP) Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Miotto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2013 Infectious Diseases Division University of Campinas (UNICAMP) Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. F. C.","family":"Mazo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2013 Gastroenterology Division (Gastrocentro) University of Campinas (UNICAMP) Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. G.","family":"Vigani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2013 Infectious Diseases Division University of Campinas (UNICAMP) Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. B. E.","family":"da Costa","sequence":"additional","affiliation":[{"name":"Department of Pathology \u2013 Hepatic Disorders Division University of Campinas (UNICAMP) Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S. B.","family":"Stucchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2013 Infectious Diseases Division University of Campinas (UNICAMP) Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R. 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