{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:32:58Z","timestamp":1790094778421,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>We systematically reviewed available evidence for reports of neurological signs and symptoms in patients with COVID\u201019 to identify cases with severe acute respiratory syndrome coronavirus (SARS\u2010CoV)\u20102 infection or immune\u2010mediated reaction in the nervous system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We followed PRISMA guidelines and used the MEDLINE, EMBASE, Google Scholar, MedRxiv and ChinaXiv databases to search for articles on COVID\u201019 and nervous system involvement that were published from 1 January to 24 April 2020. Data on design, sample size, neurological assessment and related work\u2010up were extracted. Biases were assessed with the Newcastle\u2013Ottawa scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analysed 27 publications on potential neuroinvasive or parainfectious neurological complications of COVID\u201019. The reports focused on smell and taste (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) and evaluation of neurological symptoms and signs in cohorts (<jats:italic>n<\/jats:italic>\u00a0=\u00a05). There were cases of Guillain\u2010Barr\u00e9 syndrome\/Miller\u2010Fisher syndrome\/cranial neuropathy (seven cases), meningitis\/encephalitis (nine cases) and various other conditions (five cases). The number of patients with examination of cerebrospinal fluid and, in particular, SARS\u2010CoV\u20102 polymerase chain reaction was negligible. Two had a positive SARS\u2010CoV\u20102 polymerase chain reaction examination of cerebrospinal fluid specimen. Study of potential parenchymal involvement with magnetic resonance imaging was rare. Only four reports received a rating of the highest quality standards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This systematic review failed to establish comprehensive insights into nervous system manifestations of COVID\u201019 beyond immune\u2010mediated complications in the aftermath of respiratory symptoms. The authors therefore provide guidance for more careful clinical, diagnostic and epidemiological studies to characterize the manifestations and burden of neurological disease caused by SARS\u2010CoV\u20102 on behalf of the Infectious Disease Panel of the European Academy of Neurology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14382","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T21:11:52Z","timestamp":1591391512000},"page":"1712-1726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["A systematic review of neurological manifestations of SARS\u2010CoV\u20102 infection: the devil is hidden in the details"],"prefix":"10.1111","volume":"27","author":[{"given":"M.","family":"Romoli","sequence":"first","affiliation":[{"name":"Neurology Unit Maurizio Bufalini Hospital Cesena Italy"},{"name":"Neurology Clinic University of Perugia \u2013 S. 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