{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T18:47:04Z","timestamp":1786214824498,"version":"build-2736575974"},"reference-count":88,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801252"],"award-info":[{"award-number":["81801252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873777"],"award-info":[{"award-number":["81873777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>Approximately 89% of patients with Parkinson\u2019s disease (PD) suffer from dysarthria. Lee Silverman Voice Treatment (LSVT), a behavioral therapy, aims to improve speech and voice functions. The objective was to assess the effectiveness of LSVT compared with other\/no speech interventions for dysarthria in patients with PD. Electronic databases, including PubMed, Embase and the Cochrane Library, were searched. The publication date of all included studies was before 6 March 2020. Only randomized controlled trials (RCTs) that evaluated the LSVT intervention compared with other\/no speech intervention were considered. The data obtained from the included studies were described and the mean differences were calculated. Eight RCTs were included in this meta\u2010analysis comparing LSVT with other\/no speech interventions. In the comparison of LSVT versus no intervention, vocal intensity for sustained \u2018Ah\u2019 phonation, reading the \u2018Rainbow passage\u2019, monologue and describing a picture increased by 8.87, 4.34, 3.25 and 3.31\u00a0dB, respectively, after 1\u00a0month of therapy. Compared with the respiratory therapy group, the LSVT group also showed significant improvement in vocal intensity for sustained \u2018Ah\u2019 phonation, reading the \u2018Rainbow passage\u2019 and monologue immediately after treatment (13.39, 6.66 and 3.19\u00a0dB). Positive improvement still existed after 24\u00a0months. There was no difference in the therapeutic effect between face\u2010to\u2010face and online LSVT. The effectiveness of LSVT for dysarthria in patients with PD was verified in these trials. However, future RCTs with sufficient participants are essential to evaluate the effectiveness of LSVT for dysarthria.<\/jats:p>","DOI":"10.1111\/ene.14399","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T14:46:05Z","timestamp":1592232365000},"page":"1957-1970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Lee Silverman Voice Treatment for dysarthria in patients with Parkinson\u2019s disease: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"27","author":[{"given":"F.","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3658-3928","authenticated-orcid":false,"given":"J.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3882-6540","authenticated-orcid":false,"given":"Q.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.04.026"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13919"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13397"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.0521"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00520"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00053"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0416"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.0112"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479927"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.110171"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000266286"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0602.85"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000232537.58310.22"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2013\/12-0259)"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2004\/058)"},{"key":"e_1_2_8_17_1","first-page":"109","article-title":"Motor instability in parkinsonian speech intensity","volume":"14","author":"Ho AK","year":"2001","journal-title":"Cogn Behav Neurol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-2009-0462"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.397755"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.54.12.1093"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2007\/064)"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2010.01.009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.4816541"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032132"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2011.10.013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(01)00010-8"},{"key":"e_1_2_8_27_1","first-page":"26","article-title":"Voice abnormalities and their relation with motor dysfunction in Parkinson\u2019s disease","volume":"117","author":"Midi I","year":"2007","journal-title":"Acta Neurol Scand"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9924(95)00037-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21996"},{"key":"e_1_2_8_30_1","first-page":"1","article-title":"Speech rate deficits in individuals with Parkinson's disease: a review of the literature","volume":"17","author":"Blanchet P","year":"2009","journal-title":"J Med Speech\u2010Lang Pa"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshr.1203.462"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/13682820701740713"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007733"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0204"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13803"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.0324"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2018.1116"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2018.0203"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afj053"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215507079096"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.5.584"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9924(99)00025-8"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2010.04.007"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcomdis.2004.09.001"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2007.04.003"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25816"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22296"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.06.010"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-191798"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181368"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617716000035"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20140193"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshr.3806.1232"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(05)80210-3"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/1460-6984.12132"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.4.493"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-018-1945-6"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169110"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27460"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617714000046"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.3109\/13682822.2010.484849"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-017-0222-z"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200101)16:1<79::AID-MDS1013>3.0.CO;2-H"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2009\/08-0184)"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/897494"},{"key":"e_1_2_8_66_1","first-page":"1","article-title":"Lee Silverman voice treatment (LSVT) mitigates voice difficulties in mild Parkinson's disease","volume":"33","author":"Saffarian A","year":"2019","journal-title":"Med J Islam Repub Iran"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.3109\/13682822.2010.484848"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1044\/2015_AJSLP-15-0005"},{"key":"e_1_2_8_69_1","first-page":"126","volume-title":"Research Synthesis Methods","author":"Shuster JJ","year":"2011"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228029300200202"},{"key":"e_1_2_8_71_1","unstructured":"AuP SackleyC.PD COMM study. ISRCTN2016."},{"key":"e_1_2_8_72_1","article-title":"Effectiveness of Lee Silverman Voice Treatment (LSVT LOUD) on voice, swallowing and cough function in Parkinson's disease: a randomized controlled trial","author":"Miles A","year":"2019","journal-title":"ACTRN"},{"key":"e_1_2_8_73_1","article-title":"The effectiveness evaluation and standardization research of new rehabilitation therapy for the speech\u2010language disorders or gait disorders in mid\u2010 to late\u2010stage Parkinson's disease patients","author":"Qing W","year":"2018","journal-title":"ChiCTR"},{"key":"e_1_2_8_74_1","article-title":"Voice therapy in Parkinson disease","author":"Wheless JW","year":"2014","journal-title":"clinicaltrials.gov"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360(2012\/11-0125)"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshr.3904.798"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360(2007\/014)"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1080\/17489539.2017.1339764"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.6.1496"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2005.04.005"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07750-4"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9406(05)60445-2"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt270"},{"key":"e_1_2_8_84_1","first-page":"1","article-title":"Publication bias in clinical trials due to statistical significance or direction of trial results","volume":"1","author":"Hopewell S","year":"2009","journal-title":"Cochrane Db Syst Rev"},{"key":"e_1_2_8_85_1","first-page":"147","article-title":"Global implementation of efficacious voice treatment for Parkinson's disease LSVT LOUD Germany, France and Japan","volume":"9","author":"Ramig L","year":"2019","journal-title":"J Parkinson Dis"},{"key":"e_1_2_8_86_1","first-page":"150","article-title":"Speech intelligibility of individuals with Parkinson's disease in noise following voice or articulation treatment","volume":"9","author":"Schulz G","year":"2019","journal-title":"J Parkinson Dis"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/391946"},{"key":"e_1_2_8_88_1","first-page":"1","article-title":"The impact of LSVT BIG therapy on postural control for individuals with Parkinson disease: a case series","author":"Fishel SC","year":"2018","journal-title":"Physiother Theory Pract"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215517734385"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.14399","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14399","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14399","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:29:20Z","timestamp":1693355360000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,12]]},"references-count":88,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/ene.14399"],"URL":"https:\/\/doi.org\/10.1111\/ene.14399","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,12]]},"assertion":[{"value":"2020-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}