{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:34:15Z","timestamp":1771068855854,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Basilar artery occlusion (BAO) leads to high rates of morbidity and mortality, despite successful recanalization. The discordance between flow restoration and long\u2010term functional status clouds clinical decision\u2010making regarding further aggressive care. We sought to develop and validate a practical, prognostic tool for the prediction of 3\u2010month favorable outcome after acute reperfusion therapy for BAO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, multicenter, observational study was conducted at four high\u2010volume stroke centers in the USA and Europe. Multivariate regression analysis was performed to identify predictors of favorable outcome (90\u2010day modified Rankin scale scores 0\u20132) and derive a clinically applicable prognostic model (the Pittsburgh Outcomes after Stroke Thrombectomy\u2010Vertebrobasilar (POST\u2010VB) score). The POST\u2010VB score was evaluated and internally validated with regard to calibration and discriminatory ability. External validity was assessed in patient cohorts at three separate centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the derivation cohort of 59 patients, independent predictors of favorable outcome included smaller brainstem infarct volume on post\u2010procedure magnetic resonance imaging (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and younger age (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). POST\u2010VB score was calculated as: age\u00a0+\u00a0(10\u00a0\u00d7\u00a0brainstem infarct volume). POST\u2010VB score demonstrated excellent discriminatory ability [area under the receiver\u2010operating characteristic curve (AUC)\u00a0=\u00a00.91] and adequate calibration (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.88) in the derivation cohort (Center A). It performed equally well across the three external validation cohorts (Center B, AUC\u00a0=\u00a00.89; Center C, AUC\u00a0=\u00a00.78; Center D, AUC\u00a0=\u00a00.80). Overall, a POST\u2010VB score\u00a0&lt;\u00a049 was associated with an 88% likelihood of favorable outcome, as compared to 4% with a score\u00a0\u2265\u00a0125.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The POST\u2010VB score effectively predicts 3\u2010month functional outcome following acute reperfusion therapy for BAO and may aid in guiding post\u2010procedural care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14406","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T21:49:35Z","timestamp":1592430575000},"page":"2176-2184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predicting outcomes after acute reperfusion therapy for basilar artery occlusion"],"prefix":"10.1111","volume":"27","author":[{"given":"A. P.","family":"Jadhav","sequence":"first","affiliation":[{"name":"Departments of Neurology and Neurosurgery University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9013-6929","authenticated-orcid":false,"given":"S. M.","family":"Desai","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neurosurgery University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Panczykowski","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neurosurgery University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rangaraju","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University and Grady Memorial Hospital Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University and Grady Memorial Hospital Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0922-2358","authenticated-orcid":false,"given":"J. K.","family":"Ritvonen","sequence":"additional","affiliation":[{"name":"Neurological Research Unit Department of Neurology, Neurocenter Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Schreiner","sequence":"additional","affiliation":[{"name":"Medizinische Fakult\u00e4t Carl Gustav Carus Technische Universit\u00e4t Dresden Department of Neurology Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Silvennoinen","sequence":"additional","affiliation":[{"name":"Helsinki Medical Imaging Center Helsinki University Hospital University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-8700","authenticated-orcid":false,"given":"J.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology Carl Gustav Carus University Hospital Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Puetz","sequence":"additional","affiliation":[{"name":"Medizinische Fakult\u00e4t Carl Gustav Carus Technische Universit\u00e4t Dresden Department of Neurology Dresden Neurovascular Center Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University and Grady Memorial Hospital Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1884-2196","authenticated-orcid":false,"given":"D. C.","family":"Haussen","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University and Grady Memorial Hospital Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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