{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:16:39Z","timestamp":1773958599136,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571158"],"award-info":[{"award-number":["81571158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Soluble ST2 (sST2) is a promising biomarker in inflammation, atherosclerosis and cardiovascular diseases. We investigated the association between serum sST2 and poor outcome in patients with transient ischaemic attack (TIA)\/ischaemic stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients within 24\u00a0h after onset and with measured serum sST2 were prospectively enrolled in this study. Poor outcome was a combination of a new stroke event (ischaemic or haemorrhagic) and all\u2010cause death within 90\u00a0days and 1\u00a0year. The associations of serum sST2 with poor outcome were analysed by Cox proportional hazards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 430 patients included, the median (interquartile range) sST2 was 17.72 (9.31\u201328.84)\u00a0ng\/mL. A total of 19 (4.4%) and 38 (8.8%) patients experienced poor outcome within 90\u00a0days and 1\u00a0year, respectively. Compared with the lowest sST2 tertile, hazard ratios (HRs) [95% confidence intervals (CI)] for the highest tertile were 5.14 (1.43\u201318.51) for poor outcome within 90\u00a0days and 3.00 (1.29\u20136.97) at 1\u00a0year after multivariate adjustments. Adding sST2 to a prediction model significantly improved risk stratification of poor outcome in TIA\/ischaemic stroke, as observed by the continuous net reclassification improvement of 60.98% (95% CI, 15.37\u2013106.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) and integrated discrimination improvement of 2.63% (95% CI, 0.08\u20135.18%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.043) at 90\u00a0days and the continuous net reclassification improvement of 41.68% (95% CI, 8.74\u201374.61%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.013) at 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased serum sST2 levels in TIA\/ischaemic stroke were associated with increased risks of poor outcome within 90\u00a0days and 1\u00a0year, suggesting that serum sST2 may be a potential long\u2010term prognostic biomarker for TIA\/ischaemic stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14419","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T21:28:29Z","timestamp":1593293309000},"page":"2202-2208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Serum soluble ST2 is a potential long\u2010term prognostic biomarker for transient ischaemic attack and ischaemic stroke"],"prefix":"10.1111","volume":"27","author":[{"given":"X.","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"},{"name":"Henan Key Laboratory of Cerebrovascular Diseases Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"},{"name":"Henan Key Laboratory of Cerebrovascular Diseases Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"},{"name":"Henan Key Laboratory of Cerebrovascular Diseases Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"},{"name":"Henan Key Laboratory of Cerebrovascular Diseases Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"},{"name":"Henan Key Laboratory of Cerebrovascular Diseases Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"},{"name":"Henan Key Laboratory of Cerebrovascular Diseases Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"},{"name":"Henan Key Laboratory of Cerebrovascular Diseases Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"},{"name":"Henan Key Laboratory of Cerebrovascular Diseases Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ning","sequence":"additional","affiliation":[{"name":"Clinical Proteomics Research Centre and Cardio\u2010Neurology Clinic Department of Neurology Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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