{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:11:50Z","timestamp":1789168310832,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Both optical coherence tomography (OCT) and magnetic resonance imaging (MRI) volumetric measures have been postulated as potential biomarkers of multiple sclerosis (MS)\u2010related disability. The aim of the study was to investigate the association between OCT and brain volume and spinal cord area (SCA) parameters in patients with relapsing MS and to assess their independent associations with disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional analysis of 90 patients with MS who underwent OCT and MRI examination. Values of peripapillary retinal nerve fibre layer (pRNFL), ganglion cell\/inner plexiform layer (GCIPL) and inner nuclear layer of eyes without previous optic neuritis were obtained. SCA and brain parenchymal fraction (BPF), grey and white matter fractions were obtained. Multivariable regression analyses were conducted with disability as dependent variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower pRNFL thickness and lower GCIPL volume as well as lower BPF, grey matter fraction and SCA were associated with a longer disease duration and a higher Expanded Disability Status Scale score. Lower pRNFL thickness and GCIPL volumes were associated with lower BPF and SCA. In the multivariable logistic regression analyses, pRNFL thickness and GCIPL volume outperformed MRI in predicting disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The OCT measures correlate with brain and spinal cord atrophy and appear more closely associated with disability than MRI volumetric measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14421","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T08:05:41Z","timestamp":1593504341000},"page":"2225-2232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Optical coherence tomography measures correlate with brain and spinal cord atrophy and multiple sclerosis disease\u2010related disability"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-5507","authenticated-orcid":false,"given":"A.","family":"Vidal\u2010Jordana","sequence":"first","affiliation":[{"name":"Servicio de Neurologia\u2010Neuroinmunologia Centro de Esclerosis M\u00faltiple de Catalu\u00f1a (Cemcat) Hospital Universitario Vall d'Hebron Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pareto","sequence":"additional","affiliation":[{"name":"Servicio de Radiologia Hospital Universitario Vall d'Hebron Unidad de Resonancia Magn\u00e9tica Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cabello","sequence":"additional","affiliation":[{"name":"Servicio de Neurologia\u2010Neuroinmunologia Centro de Esclerosis M\u00faltiple de Catalu\u00f1a (Cemcat) Hospital Universitario Vall d'Hebron Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alberich","sequence":"additional","affiliation":[{"name":"Servicio de Radiologia Hospital Universitario Vall d'Hebron Unidad de Resonancia Magn\u00e9tica Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rio","sequence":"additional","affiliation":[{"name":"Servicio de Neurologia\u2010Neuroinmunologia Centro de Esclerosis M\u00faltiple de Catalu\u00f1a (Cemcat) Hospital Universitario Vall d'Hebron Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tintore","sequence":"additional","affiliation":[{"name":"Servicio de Neurologia\u2010Neuroinmunologia Centro de Esclerosis M\u00faltiple de Catalu\u00f1a (Cemcat) Hospital Universitario Vall d'Hebron Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Auger","sequence":"additional","affiliation":[{"name":"Servicio de Radiologia Hospital Universitario Vall d'Hebron Unidad de Resonancia Magn\u00e9tica Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Montalban","sequence":"additional","affiliation":[{"name":"Servicio de Neurologia\u2010Neuroinmunologia Centro de Esclerosis M\u00faltiple de Catalu\u00f1a (Cemcat) Hospital Universitario Vall d'Hebron Barcelona"},{"name":"Division of Neurology University of Toronto St Michael\u00b4s Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rovira","sequence":"additional","affiliation":[{"name":"Servicio de Radiologia Hospital Universitario Vall d'Hebron Unidad de Resonancia Magn\u00e9tica Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sastre\u2010Garriga","sequence":"additional","affiliation":[{"name":"Servicio de Neurologia\u2010Neuroinmunologia Centro de Esclerosis M\u00faltiple de Catalu\u00f1a (Cemcat) Hospital Universitario Vall d'Hebron Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30481-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70349-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018172468"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2017.01.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30278-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.573"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww219"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.0377"},{"key":"e_1_2_6_10_1","first-page":"1","article-title":"Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis; 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