{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:59:51Z","timestamp":1776121191056,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201011\u2010JSH2\u2010006\u20101"],"award-info":[{"award-number":["ANR\u201011\u2010JSH2\u2010006\u20101"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201017\u2010EURE\u20100017"],"award-info":[{"award-number":["ANR\u201017\u2010EURE\u20100017"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Different amounts of cumulative exposure to the toxic mutant form of the huntingtin protein might underlie the distinctive pattern of striatal connectivity in pre\u2010manifest Huntington\u2019s disease (pre\u2010HD). The aim of this study was to investigate disease\u2010burden\u2010dependent cortical\u2010striatal and subcortical\u2010striatal loops at different pre\u2010HD stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 16 participants with pre\u2010HD and 25 controls underwent magnetic resonance imaging to investigate striatal structural and functional connectivity (FC). Individuals with pre\u2010HD were stratified into far\u2010from\u2010onset and close\u2010to\u2010onset disease groups according to the disease\u2010burden score. Cortical\u2010striatal and subcortical\u2010striatal FC was investigated through seed\u2010region of interest (ROI) and ROI\u2010to\u2010ROI approaches, respectively. The integrity of white\u2010matter pathways originating from striatal seeds was investigated through probabilistic tractography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In far\u2010from\u2010onset pre\u2010HD, the left caudate nucleus showed cortical increased FC in brain regions overlapping with the default mode network and increased coupling connectivity with the bilateral thalamus. By contrast, close\u2010to\u2010onset individuals showed increased fractional anisotropy (and mean diffusivity) in the right caudate nucleus and widespread striatal atrophy. Finally, we reported an association between cortical\u2010caudate FC and caudate structural connectivity, although this did not survive multiple comparison correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Functional reorganization of the caudate nucleus might underlie plasticity compensatory mechanisms that recede as individuals with pre\u2010HD approach clinical symptom onset and neurodegeneration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14423","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T10:15:03Z","timestamp":1593512103000},"page":"2147-2157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Striatal connectivity in pre\u2010manifest Huntington\u2019s disease is differentially affected by disease 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