{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T20:07:01Z","timestamp":1774901221240,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011566","name":"Marga und Walter Boll-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Primitive reflexes may reoccur in various neurodegenerative diseases. However, little is known about their structural and functional correlates in the human brain. Notably, the neural mechanisms underlying a positive palmomental reflex (PMR) are poorly understood. As recent studies link Alzheimer's disease (AD)\u2010related primitive reflexes to a dysfunction of the corticostriatal motor circuit (CMC), we conducted the present study to investigate functional and structural correlates of a positive PMR. We hypothesized an involvement of frontostriatal structures and an impairment of the CMC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using whole\u2010brain resting\u2010state functional connectivity (FC), hypothesis and FC result\u2010based probabilistic tractography, and voxel\u2010based morphometry analyses, we compared two groups of AD patients with either positive (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) or negative PMR (<jats:italic>n<\/jats:italic>\u00a0=\u00a012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences in grey matter volume or structural connectivity (SC) could be observed between the PMR\u2010positive and PMR\u2010negative groups. In contrast, the PMR\u2010positive group showed a decreased seed\u2010to\u2010voxel FC between the bilateral supplementary motor area and parts of the right\u2010hemispherical caudate nucleus and thalamus and a decreased region of interest (ROI)\u2010to\u2010ROI FC between the left putamen and the left superior frontal gyrus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Data suggest that dysfunction of the CMC reflected by decreased FC underlies a positive PMR in patients with AD. The lack of significant grey matter or SC differences might reflect that changes in FC appear before changes in SC in the structures of the CMC and brain atrophy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14443","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T08:47:10Z","timestamp":1594975630000},"page":"2405-2414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Aberrant frontostriatal connectivity in Alzheimer's disease with positive palmomental reflex"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-4978","authenticated-orcid":false,"given":"H.","family":"Gramespacher","sequence":"first","affiliation":[{"name":"Department of Neurology Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Neurology Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"},{"name":"Cognitive Neuroscience Research Center J\u00fclich Institute of Neuroscience and Medicine (INM3) Research Centre Juelich Juelich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Edwin Thanarajah","sequence":"additional","affiliation":[{"name":"Department of Neurology Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"},{"name":"Max Planck Institute for Metabolism Research Cologne Germany"},{"name":"Department of Psychiatry Psychosomatic Medicine and Psychotherapy University Hospital Frankfurt Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. I. L.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Faculty of Health, Medicine and Life Sciences School for Mental Health and Neuroscience Alzheimer Centre Limburg; Maastricht University Maastricht The Netherlands"},{"name":"Gordon Center of Medical Imaging Department of Radiology Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. N. 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