{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:41:37Z","timestamp":1788964897352,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T00:00:00Z","timestamp":1597536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Neuromodulation is a promising approach to increasing motor recovery in stroke; however, to date, there is a scarcity of evidence documenting the clinical potential of transcranial direct current stimulation (tDCS) administered in the acute phase of stroke. The present study aims to examine the clinical effects of a treatment involving the application of tDCS in the acute stage post\u2010stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, double\u2010blind, sham\u2010controlled trial. A cohort of 32 stroke patients with severe motor impairment underwent 5 days of treatment with real or sham bi\u2010hemispheric tDCS over the motor cortex. During the treatment, tDCS was applied twice per day (two daily applications each of 15\u00a0min), starting 48 to 72\u00a0h after stroke onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found statistically significant improvements after both real and sham tDCS treatments in primary (hand grip strength, Motricity Index) and secondary (National Institutes of Health Stroke Scale score, Barthel Index) outcomes. Patients receiving real tDCS showed a larger improvement of upper\u2010limb muscle strength at the end of treatment phase; this advantage was no longer present after 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transcranial direct current stimulation may be used to accelerate the rate of upper\u2010limb motor recovery during the spontaneous recovery period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14451","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T20:10:32Z","timestamp":1595448632000},"page":"2473-2482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Bi\u2010hemispheric transcranial direct current stimulation for upper\u2010limb hemiparesis in acute stroke: a randomized, double\u2010blind, sham\u2010controlled trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2921-8658","authenticated-orcid":false,"given":"N.","family":"Bolognini","sequence":"first","affiliation":[{"name":"Department of Psychology and Milan Center for Neuroscience (NeuroMi) University of Milano\u2010Bicocca Milan Italy"},{"name":"Neuropsychological Laboratory IRCCS Istituto Auxologico Italiano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Psychology and Milan Center for Neuroscience (NeuroMi) University of Milano\u2010Bicocca Milan Italy"},{"name":"Neurology \u2010 Stroke Unit A. 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