{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:39:34Z","timestamp":1790185174461,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Mechanical thrombectomy (MT) is the standard of care for patients with anterior circulation large vessel occlusion. Early neurological improvement (ENI), defined as a reduction of\u00a0\u2265\u00a08 on the National Institutes of Health Stroke Scale (NIHSS) compared with baseline score, or an NIHSS score of 0 or 1 at 24\u00a0h after MT, is a strong predictor of 3\u2010month favorable outcome in such patients. The impact of ENI after MT in stroke patients with basilar artery occlusion (BAO) on 3\u2010month outcome is not clear. We aimed to study the effects of ENI in patients with BAO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of a multicenter prospective cohort of all consecutive stroke patients with BAO who underwent MT. We compared clinical outcomes between BAO patient groups according to ENI status. Multivariate analyses were performed to determine the impact of ENI on favorable 90\u2010day outcome (modified Rankin scale score 0\u20133) and to report factors contributing to ENI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 237 patients were included. ENI was observed in 70 patients (30%). Outcomes were significantly better in ENI\u2010positive patients, with 84% achieving favorable outcome (mRS score 0\u20133) at 3\u00a0months versus 30% for ENI\u2010negative patients (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001). In multivariate analysis, ENI was an independent predictive factor associated with higher rates of favorable outcome {odds ratio (OR) 18.12 [95% confidence interval (CI) 3.95\u201383.10]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001}. Higher number of passes [OR 0.62 (95% CI 0.43\u20130.89); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010] and need for stenting [OR 0.27 (95% CI 0.07\u20130.95); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.041] were negatively associated with ENI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early neurological improvement on day 1 following MT for BAO is a strong independent predictor of a favorable 3\u2010month clinical outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14487","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T12:30:51Z","timestamp":1598617851000},"page":"117-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Neurological improvement predicts clinical outcome after acute basilar artery stroke thrombectomy"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7281-1652","authenticated-orcid":false,"given":"A.","family":"Guenego","sequence":"first","affiliation":[{"name":"Department of Interventional Neuroradiology Fondation Rothschild Hospital Paris France"},{"name":"Department of Interventional Neuroradiology Erasme University Hospital Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6506-4019","authenticated-orcid":false,"given":"R.","family":"Bourcier","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Neuroradiology University Hospital of Nantes, L\u2019institut du thorax Inserm 1087 CNRS UNIV Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Guillen","sequence":"additional","affiliation":[{"name":"Neurovascular Unit Centre Hospitalier Universitaire Pontchaillou Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Weisenburger\u2010Lile","sequence":"additional","affiliation":[{"name":"Neurovascular Unit Foch Hospital Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lapergue","sequence":"additional","affiliation":[{"name":"Neurovascular Unit Foch Hospital Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gory","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Neuroradiology Universit\u00e9 de Lorraine CHRU\u2010Nancy Nancy France"},{"name":"IADI INSERM U1254 Universit\u00e9 de Lorraine Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Richard","sequence":"additional","affiliation":[{"name":"Stroke Unit Department of Neurology Universit\u00e9 de Lorraine CHRU\u2010Nancy Nancy France"},{"name":"INSERM U1116 CHRU\u2010Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ducroux","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Fondation Rothschild Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Piotin","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Fondation Rothschild Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Blanc","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Fondation Rothschild Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Labreuche","sequence":"additional","affiliation":[{"name":"ULR 2694\u2010METRICS: Evaluation Des Technologies De Sant\u00e9 et des Pratiques M\u00e9dicales Univ. 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