{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T07:29:47Z","timestamp":1777361387275,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Comorbidity of acute ischaemic stroke with Covid\u201019 is a challenging condition, potentially influencing the decision of whether to administer intravenous thrombolysis (IVT). We aimed to assess the 1\u2010month outcome in ischaemic stroke patients with Covid\u201019 infection who received IVT alone or before thrombectomy (bridging therapy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As a collaboration initiative promoted by the Italian Stroke Organization, all Italian stroke units (<jats:italic>n<\/jats:italic>\u00a0=\u00a0190) were contacted and invited to participate in data collection on stroke patients with Covid\u201019 who received IVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010five invited centers agreed to participate. Thirty patients received IVT alone and 17 received bridging therapy between 21 February 2020 and 30 April 2020 in 20 centers (<jats:italic>n<\/jats:italic>\u00a0=\u00a018, Northern Italy; <jats:italic>n<\/jats:italic>\u00a0=\u00a02, Central Italy). At 1\u00a0month, 14 (30.4%) patients died and 20 (62.5%) survivors had a modified Rankin Scale (mRS) score of 3 to 5. At 24 to 36\u00a0hours, asymptomatic intracerebral hemorrhage (ICH) was reported in eight (17.4%) patients and symptomatic ICH (sICH) in two (4.3%) patients. Causes of death were severe ischaemic stroke (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), a new ischaemic stroke (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), acute respiratory failure (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), acute renal failure (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), acute myocardial infarction (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), and endocarditis (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). In survivors with a 1\u2010month mRS score of 3 to 5, baseline glucose level was higher, whereas endovascular procedure time in cases of bridging therapy was longer. Baseline National Institutes of Health Stroke Scale glucose and creatinine levels were higher in patients who died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravenous thrombolysis for patients with stroke and Covid\u201019 was not a rare event in the most affected areas by pandemic, and rates of 1\u2010month unfavorable outcomes were high compared to previous data from the pre\u2013Covid\u201019 literature. However, risk of sICH was not increased.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14511","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T07:25:49Z","timestamp":1600673149000},"page":"2641-2645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Thrombolysis and bridging therapy in patients with acute ischaemic stroke and Covid\u201019"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3534-3201","authenticated-orcid":false,"given":"M.","family":"Cappellari","sequence":"first","affiliation":[{"name":"Stroke Unit Department of Neuroscience Azienda Ospedaliera Universitaria Integrata Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zini","sequence":"additional","affiliation":[{"name":"IRCCS Istituto di Scienze Neurologiche di Bologna Department of Neurology and Stroke Center Maggiore Hospital Bologna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sangalli","sequence":"additional","affiliation":[{"name":"UO di Neurologia\u2010Stroke Unit Ospedale Alessandro Manzoni\u2013ASST Lecco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cavallini","sequence":"additional","affiliation":[{"name":"UC Malattie Cerebrovascolari\u2013Stroke Unit IRCCS Fondazione Mondino Pavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Reggiani","sequence":"additional","affiliation":[{"name":"Neurologia ASLTO3 Rivoli"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. N.","family":"Sepe","sequence":"additional","affiliation":[{"name":"Stroke Unit\u2013Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo Alessandria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0423-8759","authenticated-orcid":false,"given":"N.","family":"Rifino","sequence":"additional","affiliation":[{"name":"Stroke Unit Ospedale Papa Giovanni XXIII Bergamo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Giussani","sequence":"additional","affiliation":[{"name":"Neurologia\u2013Stroke Unit ASST Grande Ospedale Metropolitano Niguarda Milan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Guidetti","sequence":"additional","affiliation":[{"name":"U.O.C. 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Bufalini\u2013AUSL Romagna Cesana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9417-2748","authenticated-orcid":false,"given":"S.","family":"Beretta","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Unit San Gerardo Hospital, ASST Monza Monza"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Sidoti","sequence":"additional","affiliation":[{"name":"UOS Stroke Unit ASST Franciacorta Chiari"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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