{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:16:45Z","timestamp":1790335005072,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T00:00:00Z","timestamp":1604793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) typically presents with respiratory illness ranging in severity. Neurological complications of the disease remain largely unknown. Herein, we discuss the case of a woman diagnosed with COVID\u201019 meningitis following two positive cerebrospinal fluid (CSF) RT\u2010PCR assays, and highlight the importance of recognizing the neurological manifestations of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>The patient was a 49\u2010year\u2010old woman with a history of hypertension who presented with non\u2010specific symptoms (fever, headache, malaise, nausea\/vomiting). Chest computed tomography (CT) revealed a lack of pulmonary involvement and oropharyngeal\/nasopharyngeal RT\u2010PCR was negative for COVID\u201019. A lumbar puncture was performed on the third day of admission and the CSF analysis elucidated a viral pattern, but the CSF bacterial culture and RT\u2010PCR assay for herpes simplex virus were both negative. Surprisingly, the CSF RT\u2010PCR for COVID\u201019 was positive. The diagnosis of COVID\u201019 meningitis was made and the patient was treated solely with Kaletra<jats:sup>\u00ae<\/jats:sup>, with a second CSF analysis confirming our unique finding 1\u00a0week later. The patient's clinical characteristics improved progressively, and she was discharged in excellent general condition after 21\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In contrast to what was originally believed, the SARS\u2010CoV\u20102 can cause meningitis in isolation, perhaps by crossing the blood\u2010brain barrier. Hence, it seems essential that physicians maintain a high index of suspicion for neurological involvement among COVID\u201019 patients, with early CSF analysis and brain imaging sometimes being indicated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14536","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T10:09:06Z","timestamp":1601201346000},"page":"2668-2669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["COVID\u201019 meningitis without pulmonary involvement with positive cerebrospinal fluid PCR"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4876-4312","authenticated-orcid":false,"given":"Z.","family":"Khodamoradi","sequence":"first","affiliation":[{"name":"Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4397-1539","authenticated-orcid":false,"given":"S. A.","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-8934","authenticated-orcid":false,"given":"M. H.","family":"Gholampoor Saadi","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Mehrabi","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Sasani","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3855-1986","authenticated-orcid":false,"given":"S.","family":"Yaghoubi","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,8]]},"reference":[{"key":"e_1_2_6_2_1","article-title":"Neurological complications of coronavirus disease (COVID\u201019): encephalopathy","volume":"12","author":"Filatov A","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_6_3_1","first-page":"1708","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"2020","author":"Guan W\u2010J","year":"2019","journal-title":"N Engl J Med"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.34172\/aim.2020.04"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1127"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050828"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.09.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05128-x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.054"},{"key":"e_1_2_6_11_1","article-title":"Neurological complications of coronavirus disease (COVID\u201019): encephalopathy, MRI brain and cerebrospinal fluid findings: case 2","volume":"12","author":"Espinosa PS","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-020-00978-4"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14536","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T22:12:25Z","timestamp":1693001545000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,8]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/ene.14536"],"URL":"https:\/\/doi.org\/10.1111\/ene.14536","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,8]]},"assertion":[{"value":"2020-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}