{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:15:36Z","timestamp":1780373736094,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Whether the reported association between migraine with aura (MA) and cardioembolic stroke may be explained by a higher rate of atrial fibrillation (AF) or by other potential cardiac sources of cerebral embolism remains to be determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the setting of a single centre cohort study of consecutive patients with acute brain ischaemia stratified by migraine status, the association between AF as well as patent foramen ovale (PFO) and migraine was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 1738 patients (1017 [58.5%] men, mean age 67.9\u00a0\u00b1\u00a014.9\u00a0years) qualified for the analysis. Aging was inversely associated with migraine, whilst women had a &gt;3\u2010fold increased disease risk (odds ratio [OR] 3.82, 95% confidence interval [CI] 2.58\u20135.66). No association between AF and history of migraine or its pathogenic subtypes was detected. Conversely, migraine was associated with PFO, both in the entire cohort (OR 1.84, 95% CI 1.07\u20133.16) and in patients aged \u226455\u00a0years (OR 2.21, 95% CI 1.16\u20134.22). This association was significant for MA (OR 2.92, 95% CI 1.32\u20136.45 in the entire cohort; OR 2.92, 95% CI 1.15\u20137.41 in patients aged \u226455\u00a0years) and in women (OR 8.23, 95% CI 2.06\u201332.77), but not for migraine without aura.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with brain ischaemia migraine is not associated with AF. Conversely, there is a probable relation between migraine, especially MA, and PFO in patients who are younger and have a more favourable vascular risk factor profile, and in women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14556","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T21:29:34Z","timestamp":1601155774000},"page":"516-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cardiac sources of cerebral embolism in people with migraine"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-1908","authenticated-orcid":false,"given":"V.","family":"De Giuli","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica Universit\u00e0 degli Studi di Brescia Brescia 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