{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:08:40Z","timestamp":1792789720219,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome, defined by a distinctive clinical\u2010radiological profile, with Alzheimer's disease (AD) pathology accounting for the majority of cases. The aim of this report was to present the case of a patient with impairment of visual and constructional abilities as initial manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The patient underwent a multidimensional assessment, including neuropsychological evaluation, structural and functional imaging and genetic screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neurological and neuropsychological assessment showed an impairment of constructive and visuo\u2010spatial skills, associated with dyscalculia, simultanagnosia, optic ataxia and oculomotor apraxia. In accordance with the latest consensus criteria, a diagnosis of PCA was made. Consistent with the clinical findings, structural and functional imaging showed a peculiar pattern of atrophy with primary involvement of right parieto\u2010occipital cortices, whereas cerebrospinal fluid biochemical analysis did not reveal a profile compatible with AD pathology. Genetic screening identified a known pathogenic <jats:italic>GRN<\/jats:italic> mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We present a case of PCA in a <jats:italic>GRN<\/jats:italic> mutation carrier in whom a concomitant AD pathological process was excluded. Consequently, although lacking histological data, our case suggests <jats:italic>GRN<\/jats:italic>\u2010related pathology causative of PCA. Through this report we provide further evidence for a new neurodegenerative pathway leading to PCA, extending the clinical spectrum of <jats:italic>GRN<\/jats:italic>\u2010associated phenotypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14574","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T18:28:45Z","timestamp":1602181725000},"page":"344-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical and radiological features of posterior cortical atrophy (PCA) in a <i>GRN<\/i> mutation carrier: a case report"],"prefix":"10.1111","volume":"28","author":[{"given":"M.","family":"Giunta","sequence":"first","affiliation":[{"name":"Centre for Neurodegenerative Disorders Department of Clinical and Experimental Sciences University of Brescia Brescia 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