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We aimed to assess the feasibility of using CSF PTPRQ concentrations for the additional diagnostic criterion of iNPH in Japanese and Finnish populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared PTPRQ concentrations among patients with probable iNPH and neurologically healthy individuals (normal control [NC] group), patients with normal\u2010pressure hydrocephalus (NPH) of acquired and congenital\/developmental aetiologies, patients with Alzheimer\u2019s disease and patients with Parkinson\u2019s disease in a Japanese analysis cohort. A corresponding iNPH group and NC group in a Finnish cohort was used for validation. Patients in the Finnish cohort who underwent biopsy were classified into two groups based on amyloid and\/or tau deposition. We measured PTPRQ expression levels in autopsied brain specimens of iNPH patients and the NC group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cerebrospinal fluid PTPRQ concentrations in the patients with NPH of idiopathic, acquired and congenital\/developmental aetiologies were significantly higher than those in the NC group and those with Parkinson\u2019s disease, but iNPH showed no significant differences when compared with those in the Alzheimer\u2019s disease group. For the patients with iNPH, the area under the receiver\u2010operating characteristic curve was 0.860 in the Japanese iNPH and 0.849 in the Finnish iNPH cohorts. Immunostaining and\n                      <jats:italic>in situ<\/jats:italic>\n                      hybridization revealed PTPRQ expression in the ependymal cells and choroid plexus. It is highly possible that the elevated PTPRQ levels in the CSF are related to ependymal dysfunction from ventricular expansion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cerebrospinal fluid PTPRQ levels indicated the validity of this assay for auxiliary diagnosis of adult chronic hydrocephalus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.14575","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T14:40:56Z","timestamp":1602254456000},"page":"389-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Protein tyrosine phosphatase receptor type Q in cerebrospinal fluid reflects ependymal cell dysfunction and is a potential biomarker for adult chronic hydrocephalus"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8496-2973","authenticated-orcid":false,"given":"M.","family":"Nakajima","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Juntendo University Faculty of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2250-327X","authenticated-orcid":false,"given":"T.","family":"Rauramaa","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine\uff0dPathology University of Eastern Finland"},{"name":"Department of Pathology Kuopio University Hospital Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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