{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:06:59Z","timestamp":1791871619004,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The purpose was to report the results of ultrasound\u2010guided lumbar puncture for the administration of nusinersen in spinal muscular atrophy (SMA) patients with complex spines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen SMA patients (five children, five adolescents and eight adults) with either severe scoliosis or spondylodesis were evaluated for ultrasound\u2010guided lumbar puncture. Ultrasound was performed with a 3.5\u00a0MHz transducer to guide a 22\u00a0gauge\u00a0\u00d7\u00a015\u00a0mm needle, which was placed in the posterior lumbar space following a parasagittal interlaminar approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve patients had undergone spinal instrumentation (nine growing rods and three spinal fusion) whilst the other six showed severe scoliosis. Success was achieved in 91\/94 attempts (96.8%), in 14\/18 patients (77.8%), including 100% of children and adolescents and 50% of adult patients. In two of the unsuccessfully treated patients, computed tomography and fluoroscopy\u2010guided transforaminal lumbar punctures were also tried without success. After a median follow\u2010up of 14\u00a0months, only few adverse events, mostly mild, were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ultrasound\u2010guided lumbar puncture, following an interlaminar parasagittal approach, is a safe and effective approach for intrathecal treatment with nusinersen in children, adolescents and carefully selected adult SMA patients with complex spines and could be considered the first option in them.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14586","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T07:47:41Z","timestamp":1602661661000},"page":"676-680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Ultrasound\u2010guided lumbar puncture for nusinersen administration in spinal muscular atrophy patients"],"prefix":"10.1111","volume":"28","author":[{"given":"D.","family":"Veiga\u2010Canuto","sequence":"first","affiliation":[{"name":"Radiology Department Hospital Universitario y Polit\u00e9cnico La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cifri\u00e1n\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Radiology Department Hospital Universitario y Polit\u00e9cnico La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Pitarch\u2010Castellano","sequence":"additional","affiliation":[{"name":"Neuromuscular Research Unit Instituto de Investigaci\u00f3n Sanitaria la Fe Valencia Spain"},{"name":"Pediatrics Department Pediatric Neurology Section Hospital Universitario y Polit\u00e9cnico La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3043-7938","authenticated-orcid":false,"given":"J.F.","family":"V\u00e1zquez\u2010Costa","sequence":"additional","affiliation":[{"name":"Neuromuscular Research Unit Instituto de Investigaci\u00f3n Sanitaria la Fe Valencia Spain"},{"name":"Motor Neuron Disease Unit Department of Neurology Hospital Universitario y Polit\u00e9cnico La Fe Valencia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) Valencia Spain"},{"name":"Department of Medicine University of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Aparici","sequence":"additional","affiliation":[{"name":"Radiology Department Hospital Universitario y Polit\u00e9cnico La Fe Valencia Spain"},{"name":"Department of Medicine University of Valencia Valencia 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