{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:18:06Z","timestamp":1784071086000,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>This was an investigation of the differential effects of early intensive versus guideline\u2010recommended blood pressure (BP) lowering between lacunar and non\u2010lacunar acute ischaemic stroke (AIS) in the BP arm of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 1,632 participants classified as having definite or probable lacunar (<jats:italic>n<\/jats:italic>\u00a0=\u00a0454 [27.8%]) or non\u2010lacunar AIS according to pre\u2010specified definitions based upon clinical and adjudicated imaging findings, mean BP changes over days 0\u20137 were plotted, and systolic BP differences by treatment between subgroups were estimated in generalized linear models. Logistic regression models were used to estimate the BP treatment effects on 90\u2010day outcomes (primary, an ordinal shift of modified Rankin scale scores) across lacunar and non\u2010lacunar AIS after adjustment for baseline covariables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most baseline characteristics, acute BP and other management differed between lacunar and non\u2010lacunar AIS, but mean systolic BP differences by treatment were comparable at each time point (all <jats:italic>p<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0&gt;\u00a00.12) and over 24\u00a0h post\u2010randomization (\u22125.5, 95% CI \u22126.5, \u22124.4\u00a0mmHg in lacunar AIS vs. \u22125.6, 95% CI \u22126.3, \u22124.8\u00a0mmHg in non\u2010lacunar AIS, <jats:italic>p<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0=\u00a00.93). The neutral effect of intensive BP lowering on functional outcome and the beneficial effect on intracranial haemorrhage were similar for the two subgroups (all <jats:italic>p<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0&gt;\u00a00.19).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were no differences in the treatment effect of early intensive versus guideline\u2010recommended BP lowering across lacunar and non\u2010lacunar AIS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14598","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T21:11:28Z","timestamp":1602969088000},"page":"783-793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intensive versus guideline\u2010recommended blood pressure reduction in acute lacunar stroke with intravenous thrombolysis therapy: The ENCHANTED trial"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6543-7113","authenticated-orcid":false,"given":"Zien","family":"Zhou","sequence":"first","affiliation":[{"name":"The George Institute for Global Health Faculty of Medicine University of New South Wales Sydney NSW Australia"},{"name":"Department of Radiology Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xia","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health Faculty of Medicine University of New South Wales Sydney NSW Australia"},{"name":"Department of Neurosurgery West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Carcel","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health Faculty of Medicine University of New South Wales 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Medicine University of New South Wales Sydney NSW Australia"},{"name":"Department of Neurology Royal Prince Alfred Hospital Sydney Health Partners Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Malavera","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health Faculty of Medicine University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Chen","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health Faculty of Medicine University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Mair","sequence":"additional","affiliation":[{"name":"Division of Neuroimaging Sciences Edinburgh Imaging and Centre for Clinical Brain Sciences University of Edinburgh 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