{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:47:09Z","timestamp":1781808429301,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>At high altitude the brain is exposed to hypoxic stress, which may result in neurological conditions, with acute mountain sickness (AMS) being the most common. We aimed to test the hypothesis that rapid ascent to high altitude alters neuro\u2010axonal integrity, which can be detected by increased concentration of serum neurofilament light (sNfL) in the blood and may even be exaggerated in people with AMS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum neurofilament light was measured using a single\u2010molecule array (Simoa, Quanterix, Lexington, MA, USA) assay at low altitude (423\u00a0m) in 47 healthy study participants and 44\u00a0h after rapid and active ascent to high altitude (4559\u00a0m). Peripheral oxygen saturation (SpO<jats:sub>2<\/jats:sub>) and partial pressures of oxygen (pO<jats:sub>2<\/jats:sub>) were obtained at low and high altitude. The Acute Mountain Sickness\u2010Cerebral (AMS\u2010C) scoring system was used to assess AMS incidence and AMS severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was an increase in sNfL from its baseline value compared with its value at high altitude (6.34\u00a0\u00b1\u00a01.96 vs. 7.19\u00a0\u00b1\u00a03.14\u00a0pg\/ml; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.014), but sNfL level did not correlate with SpO<jats:sub>2<\/jats:sub> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.19; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.066) or pO<jats:sub>2<\/jats:sub> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.19; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.068). The incidence of AMS at high altitude was 62%. Neither at low altitude (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.706) nor at high altitude (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.985) was there a difference in sNfL between participants with and without AMS as measured 3\u00a0days after rapid ascent and 44\u00a0h of high\u2010altitude exposure. Altitude sNfL did not correlate with AMS\u2010C, either overall or with single\u2010item scores such as headache severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rapid ascent of healthy people to high altitude provokes an increase in sNfL 44\u00a0h after arrival at 4559\u00a0m, which is not related to the magnitude of hypoxemia or AMS incidence and severity, suggesting that neuro\u2010axonal injury does not directly contribute to AMS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14606","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T18:38:32Z","timestamp":1603478312000},"page":"1004-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Serum neurofilament level increases after ascent to 4559\u00a0m but is not related to acute mountain sickness"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-0505","authenticated-orcid":false,"given":"Mahdi","family":"Sareban","sequence":"first","affiliation":[{"name":"University Institute of Sports Medicine, Prevention and Rehabilitation, University Hospital Salzburg, Paracelsus Medical University Salzburg Austria"},{"name":"Research Institute of Molecular Sports Medicine and Rehabilitation Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6771-3193","authenticated-orcid":false,"given":"Marc Moritz","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine University Hospital Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-5225","authenticated-orcid":false,"given":"Daniela","family":"Pinter","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arabella","family":"Buchmann","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Macholz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and General Critical Care Medicine University Hospital Salzbur, Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and General Critical Care Medicine University Hospital Salzbur, Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Schiefer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and General Critical Care Medicine University Hospital Salzbur, Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Schimke","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and General Critical Care Medicine University Hospital Salzbur, Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Niebauer","sequence":"additional","affiliation":[{"name":"University Institute of Sports Medicine, Prevention and Rehabilitation, University Hospital Salzburg, Paracelsus Medical University Salzburg Austria"},{"name":"Research Institute of Molecular Sports Medicine and Rehabilitation Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen Michael","family":"Steinacker","sequence":"additional","affiliation":[{"name":"Division of Sports and Rehabilitation Medicine University Hospital Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5388-4282","authenticated-orcid":false,"given":"Gunnar","family":"Treff","sequence":"additional","affiliation":[{"name":"Division of Sports and Rehabilitation Medicine University Hospital Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5350-3328","authenticated-orcid":false,"given":"Michael","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/1527029041352108"},{"key":"e_1_2_8_3_1","first-page":"1666","article-title":"Acute high\u2010altitude illnesses","volume":"369","author":"B\u00e4rtsch P","year":"2013","journal-title":"N Engl J Med"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0058-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14612-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00982-2017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0096-2016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1641"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.37.2.247"},{"key":"e_1_2_8_10_1","first-page":"1063","article-title":"Procedures for 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