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To date, the earliest and most sensitive of these is caudate volume; however, it is becoming increasingly evident that numerous changes to cortical structures, and their interconnected networks, occur throughout the course of the disease. The mechanisms by which atrophy spreads from the caudate to these cortical regions remains unknown. In this review, the neuroimaging literature specific to T1\u2010weighted and diffusion\u2010weighted magnetic resonance imaging is summarized and new strategies for the investigation of cortical morphometry and the network spread of degeneration in HD are proposed. This new avenue of research may enable further characterization of disease pathology and could add to a suite of biomarker\/s of disease progression for patient stratification that will help guide future clinical trials.<\/jats:p>","DOI":"10.1111\/ene.14648","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T17:39:28Z","timestamp":1605807568000},"page":"1406-1419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cortical morphometry and neural dysfunction in Huntington\u2019s disease: a review"],"prefix":"10.1111","volume":"28","author":[{"given":"Brendan","family":"Tan","sequence":"first","affiliation":[{"name":"School of Psychological Sciences Turner Institute for Brain and Mental Health Monash University Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosita","family":"Shishegar","sequence":"additional","affiliation":[{"name":"School 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