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We analyze the accuracy of these CSF markers for diagnosis of AD in reference to brain amyloid positron emission tomography (PET). We also investigated whether they help in differentiating AD from other dementias and examined their influence in tracing the progression to dementia. Methods: Amyloid\u2010\u03b2 (A\u03b2) 1\u201342, total tau (t\u2010tau), phosphorylated tau, A\u03b2<jats:sub>40<\/jats:sub>, A\u03b2<jats:sub>38<\/jats:sub>, beta\u2010site amyloid precursor protein cleaving enzyme 1 (BACE\u20101), neurogranin (ng), phosphorylated neurofilament heavy\u2010chain, and \u03b1\u2010synuclein (\u03b1\u2010syn) CSF levels were analyzed in 319 subjects, among whom 57 also underwent an amyloid PET scan. We also analyzed longitudinal clinical data from 239 subjects. Results: Emerging CSF markers, especially ng\/BACE\u20101 ratio (area under the curve = 0.77) and their combinations with core AD CSF markers (all AUCs &gt;0.85), showed high accuracy to discriminate amyloid PET positivity. Subjects with AD had higher CSF BACE\u20101, ng, and \u03b1\u2010syn levels than those with non\u2010AD dementia. CSF t\u2010tau\/\u03b1\u2010syn ratio was higher in subjects with dementia with Lewy bodies than in those with frontotemporal dementia. Most emerging\/core AD ratios predicted a faster conversion from mild cognitive impairment (MCI) stage to AD and appeared to be helpful when core AD CSF markers were discordant. In addition, the rate of cognitive decline was associated with all CSF core AD markers, several emerging\/core AD two\u2010marker ratios, and CSF ng levels. Conclusions: These results suggest that emerging biomarkers in conjunction with core AD markers improve diagnosis of AD, are associated with the conversion from MCI into AD, and predict a faster progression of dementia.<\/jats:p>","DOI":"10.1111\/ene.14658","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T07:40:31Z","timestamp":1606290031000},"page":"1142-1152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Added value of cerebrospinal fluid multimarker analysis in diagnosis and progression of dementia"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8537-3935","authenticated-orcid":false,"given":"Ignacio","family":"\u00c1lvarez","sequence":"first","affiliation":[{"name":"Memory Disorders Unit Department of Neurology Hospital Universitari Mutua de Terrassa Terrassa Spain"},{"name":"Fundaci\u00f3 per a la Recerca Biom\u00e8dica i Social 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