{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:51:57Z","timestamp":1792144317948,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>\n                      To explore the feasibility of a neuroprotection trial in prodromal synucleinopathy, using idiopathic rapid eye movement sleep behavior disorder (iRBD) as the target population and\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010FP\u2010CIT\u2010SPECT as a biomarker of disease progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Consecutive iRBD patients were randomly assigned to a treatment arm receiving selegiline and symptomatic rapid eye movement sleep behavior disorder treatment, or to a control arm receiving symptomatic treatment only. Selegiline was chosen because of a demonstrated neuroprotection effect in animal models. Patients underwent\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010FP\u2010CIT\u2010SPECT at baseline and after 30\u00a0months on average. The clinical outcome was the emergence of parkinsonism and\/or dementia. A repeated\u2010measures general linear model (GLM) was applied using group (control and treatment) as \u201dbetween\u201d factor, and both time (baseline and follow\u2010up) and regions (\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010FP\u2010CIT\u2010SPECT putamen and caudate uptake) as the \u201dwithin\u201d factors, adjusting for age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty iRBD patients completed the study (68.2\u00a0\u00b1\u00a06.9\u00a0years; 29 males; 21% dropout rate), 13 in the treatment arm, and 17 in the control arm. At follow\u2010up (29.8\u00a0\u00b1\u00a09.0\u00a0months), three patients in the control arm developed dementia and one parkinsonism, whereas two patients in the treatment arm developed parkinsonism. Both putamen and caudate uptake decreased over time in the control arm. In the treatment arm, only the putamen uptake decreased over time, whereas caudate uptake remained stable. GLM analysis demonstrated an effect of treatment on the\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010FP\u2010CIT\u2010SPECT uptake change, with a significant interaction between the effect of group, time, and regions (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A 30\u2010months neuroprotection study for prodromal synucleinopathy is feasible, using iRBD as the target population and\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010FP\u2010CIT\u2010SPECT as a biomarker of disease progression.\n                    <\/jats:p>\n                  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