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We detected echolalia in unstructured conversations. An evaluation of language function and the presence of parkinsonism, grasp reflex, imitation behaviour, and disinhibition were assessed. We also measured regional cerebral blood flow (rCBF) using single\u2010photon emission computed tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Echolalia was observed in 12 nfvPPA and 2 unclassified PPA patients. All patients showed mitigated echolalia. We compared nfvPPA patients with echolalia (echolalia group) to those without echolalia (non\u2010echolalia group). The median age of the echolalia group was significantly lower than that of the non\u2010echolalia group, and the echolalia group showed a significantly worse auditory comprehension performance than the non\u2010echolalia group. In contrast, the performance of repetition tasks was not different between the two groups. The prevalence of imitation behaviour in the echolalia group was significantly higher than that in the non\u2010echolalia group. The rCBFs in the bilateral pre\u2010supplementary motor area and bilateral middle cingulate cortex in the echolalia group were significantly lower than those in the non\u2010echolalia group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that echolalia is characteristic of nfvPPA patients with impaired comprehension. Reduced inhibition of the medial frontal cortex with release activity of the anterior perisylvian area account for the emergence of echolalia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14673","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T09:01:50Z","timestamp":1607677310000},"page":"1113-1122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Echolalia in patients with primary progressive aphasia"],"prefix":"10.1111","volume":"28","author":[{"given":"Shoko","family":"Ota","sequence":"first","affiliation":[{"name":"Department of Behavioral Neurology and Cognitive Neuroscience Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4140-0919","authenticated-orcid":false,"given":"Shigenori","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Behavioral 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