{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:55:26Z","timestamp":1791219326333,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>The aims of this study were to describe the clinical manifestations of functional motor disorders (FMDs) coexisting with other neurological diseases (\u201ccomorbid FMDs\u201d), and to compare comorbid FMDs with FMDs not overlapping with other neurological diseases (\u201cpure FMDs\u201d).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>For this multicenter observational study, we enrolled outpatients with a definite FMD diagnosis attending 25 tertiary movement disorder centers in Italy. Each patient with FMDs underwent a detailed clinical assessment including screening for other associated neurological conditions. Group comparisons (comorbid FMDs vs. pure FMDs) were performed in order to compare demographic and clinical variables. Logistic regression models were created to estimate the adjusted odds ratios (95% confidence intervals) of comorbid FMDs (dependent variable) in relation to sociodemographic and clinical characteristics (independent variables).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 410 FMDs, 21.7% of patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a089) had comorbid FMDs. The most frequent coexisting neurological diseases were migraine, cerebrovascular disease and parkinsonism. In the majority of cases (86.5%), FMDs appeared after the diagnosis of a neurological disease. Patients with comorbid FMDs were older, and more frequently had tremor, non\u2010neurological comorbidities, paroxysmal non\u2010epileptic seizures, major depressive disorders, and benzodiazepine intake. Multivariate regression analysis showed that diagnosis of comorbid FMDs was more likely associated with longer time lag until the final diagnosis of FMD, presence of tremor and non\u2010neurological comorbidities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings highlight the need for prompt diagnosis of FMDs, given the relatively high frequency of associated neurological and non\u2010neurological diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.14674","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T17:16:11Z","timestamp":1607620571000},"page":"1752-1758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Functional motor disorders associated with other neurological diseases: Beyond the boundaries of \u201corganic\u201d neurology"],"prefix":"10.1111","volume":"28","author":[{"given":"Michele","family":"Tinazzi","sequence":"first","affiliation":[{"name":"Neurology Unit Movement Disorders Division Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6095-1930","authenticated-orcid":false,"given":"Christian","family":"Geroin","sequence":"additional","affiliation":[{"name":"Neurology Unit Movement Disorders Division Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-7419","authenticated-orcid":false,"given":"Roberto","family":"Erro","sequence":"additional","affiliation":[{"name":"Department of Medicine Surgery and Dentistry \u2010Scuola Medica Salernitana Center for Neurodegenerative Diseases (CEMAND) University of Salerno Baronissi SA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Marcuzzo","sequence":"additional","affiliation":[{"name":"Neurology Unit Movement Disorders Division Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Cuoco","sequence":"additional","affiliation":[{"name":"Department of Medicine Surgery and Dentistry \u2010Scuola Medica Salernitana Center for Neurodegenerative Diseases (CEMAND) University of Salerno Baronissi SA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1412-9406","authenticated-orcid":false,"given":"Roberto","family":"Ceravolo","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Clinical and Experimental Medicine University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Mazzucchi","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Clinical and Experimental Medicine University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pilotto","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Clinical and Experimental Sciences University of Brescia Brescia Italy"},{"name":"FERB Onlus, Ospedale S. 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