{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:56:30Z","timestamp":1762642590027,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>This case illustrates for the first time the clinical and radiological evolution of SARS\u2010CoV\u20102 meningo\u2010encephalitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case of a SARS\u2010CoV\u20102 meningo\u2010encephalitis is reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 65\u2010year\u2010old man with COVID\u201019 presenting with meningo\u2010encephalitis without respiratory involvement is described. He had fever, diarrhea and vomiting, followed by diplopia, urinary retention and sleepiness. Examination disclosed a convergence strabismus and ataxia. Cerebrospinal fluid (CSF) showed lymphocytic pleocytosis, oligoclonal bands and increased interleukin 6 level. SARS\u2010CoV\u20102 was detected in the CSF through reverse transcriptase polymerase chain reaction, but not in nasopharyngeal, tracheal secretion and rectal samples. Brain magnetic resonance imaging showed lesions on white matter hemispheres, the body and splenium of the corpus callosum and resembling the projection of corticospinal tract, remarkably on cerebellar peduncles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This demonstrates the challenges in diagnosing COVID\u201019 in patients with neurological presentations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14687","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T14:42:07Z","timestamp":1631716927000},"page":"3530-3532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical and radiological features of severe acute respiratory syndrome coronavirus 2 meningo\u2010encephalitis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3178-0460","authenticated-orcid":false,"given":"Gabriel R.","family":"de Freitas","sequence":"first","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR) Rio de Janeiro Brazil"},{"name":"Neurology Service Universidade Federal Fluminense (UFF) Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3517-3238","authenticated-orcid":false,"given":"Marcos Ravi","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Neurology Service Universidade Federal Fluminense (UFF) Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Vianna","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Cl\u00ednica S\u00e3o Vicente Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Ot\u00e1vio","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Neurolife Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helio M.","family":"Torres\u2010Filho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Richet Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea F. A.","family":"Martins","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Cl\u00ednica S\u00e3o Vicente Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Tovar\u2010Moll","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR) Rio de Janeiro Brazil"},{"name":"Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo F.","family":"Barroso","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Hospital Universit\u00e1rio Clementino Fraga Filho School of Medicine Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.04.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.062"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.04.024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020201187"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.05.022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25783"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.05.012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw203"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.05.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01903-19"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11090821"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14687","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14687","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:02:14Z","timestamp":1693342934000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/ene.14687"],"URL":"https:\/\/doi.org\/10.1111\/ene.14687","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"type":"print","value":"1351-5101"},{"type":"electronic","value":"1468-1331"}],"subject":[],"published":{"date-parts":[[2021,9,15]]},"assertion":[{"value":"2020-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}