{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:11:28Z","timestamp":1792069888116,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2018\u201002532"],"award-info":[{"award-number":["#2018\u201002532"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Charcot\u2010Marie\u2010Tooth (CMT) disease is a chronic, slowly progressing disorder. The lack of specific disease progression biomarkers limits the execution of clinical trials. However, neurofilament light chain (NfL) has been suggested as a potential biomarker for peripheral nervous system disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety\u2010six CMT disease patients and 60 healthy controls were enrolled in the study. Disease severity assessment included clinical evaluation with CMT Neuropathy Score version 2 (CMTNSv2). Blood plasma NfL concentrations were measured using the single\u2010molecule array NfL assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The NfL concentration was significantly higher in the CMT disease patient group than in the controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Of the CMT disease patients, those with type CMTX1 had a higher NfL level than those in the two other analysed subgroups (CMT1A and other CMT disease types) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0498). The NfL concentration had a significant but weak correlation with the CMTNSv2 (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a00.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012). In one CMT disease patient with an extremely elevated NfL level, overlap with chronic inflammatory demyelinating polyneuropathy was suspected. Receiver operating characteristic analysis showed that an NfL concentration of 8.9\u00a0pg\/ml could be used to discriminate CMT disease patients from controls, with an area under the curve of 0.881.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study confirmed that the plasma NfL concentration is significantly higher in CMT disease patients than in controls. Plasma NfL concentration was found to significantly, albeit weakly, reflect the clinical severity of CMT disease. In the future, NfL may be used, either individually or collaboratively, as a biomarker in the clinical context of suspected CMT disease; however, several issues need to be addressed first.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.14689","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T06:28:47Z","timestamp":1608359327000},"page":"974-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Plasma neurofilament light chain as a potential biomarker in Charcot\u2010Marie\u2010Tooth disease"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-122X","authenticated-orcid":false,"given":"Elina","family":"Millere","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery Children's Clinical University Hospital Riga Latvia"},{"name":"Department of Doctoral Studies Riga Stradins University Riga 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M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einars","family":"Kupats","sequence":"additional","affiliation":[{"name":"Department of Neurology Riga East Clinical University Hospital Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieva","family":"Micule","sequence":"additional","affiliation":[{"name":"Clinic of Medical Genetics and Prenatal Diagnostics Children's Clinical University Hospital Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktorija","family":"Priedite","sequence":"additional","affiliation":[{"name":"BIOCON Laboratory Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalja","family":"Kurjane","sequence":"additional","affiliation":[{"name":"Department of Biology and Microbiology Riga Stradins University Riga Latvia"},{"name":"Outpatient Service Centre Pauls Stradins Clinical University Hospital Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Gailite","sequence":"additional","affiliation":[{"name":"Scientific Laboratory of Molecular Genetics Riga Stradins University Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital M\u00f6lndal 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