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After clinical assessment, the 92 patients underwent baseline magnetic resonance imaging (MRI) followed by a single\u2010dose injection of BoNT\u2010A. Four weeks later, 76 out of the 92 patients were re\u2010evaluated with the Tsui scale for dystonia severity, and 33 out of 76 patients completed post\u2010treatment MRI scanning. Data\u2010driven global brain connectivity and regional homogeneity in tandem with seed\u2010based connectivity analyses were used to examine the functional abnormalities in CD and longitudinal circuit alterations that scaled with clinical response to BoNT\u2010A. Multiple regression models were employed for the prediction analysis of treatment efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cervical dystonia patients exhibited elevated baseline connectivity of the right postcentral gyrus with the left dorsomedial prefrontal cortex and right caudate nucleus, which was associated with their symptom severity. BoNT\u2010A reduced excessive functional connectivity between the sensorimotor cortex and right superior frontal gyrus, which was significantly correlated with changes in Tsui score. Moreover, pre\u2010treatment regional homogeneity of the left middle frontal gyrus was linearly related to varied response to treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings unravel dissociable connectivity of the sensorimotor cortex underlying the pathology of CD and central effects of BoNT\u2010A therapy. Furthermore, baseline regional homogeneity with the left middle frontal gyrus may represent a potential evidence\u2010based marker of patient stratification for BoNT\u2010A therapy in CD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14695","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T21:11:10Z","timestamp":1608671470000},"page":"1537-1547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Brain connectivity abnormalities and treatment\u2010induced restorations in patients with cervical dystonia"],"prefix":"10.1111","volume":"28","author":[{"given":"Liang","family":"Feng","sequence":"first","affiliation":[{"name":"Neurotoxin Research Center of Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Department of Neurology Tongji Hospital Tongji University School of Medicine Shanghai 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